Reward modulation of prefrontal and visual association cortex during an incentive working memory task
Reward modulation of prefrontal and visual association cortex during an incentive working memory task
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DOI：
10.1016/j.brainres.2007.01.052
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发表时间：
2007-04-13
期刊：
影响因子：
2.9
通讯作者：
D'Esposito, Mark
中科院分区：
文献类型：
--
作者：
Krawczyk, Daniel C.;Gazzaley, Adam;D'Esposito, Mark
认知表现与动机不同，但很少有直接的证据存在关于奖励动机对工作记忆（Vim）的影响的神经机制。我们在视觉Vim中测试了动机对自上而下控制的影响。对相关刺激进行编码以维持，同时抑制不适当的输入被认为是认知的核心过程。先前的功能性磁共振成像（fMRI）结果表明，刺激特异性视觉关联皮层用作任务相关和任务无关输入的激活差异的标记，使得当注意力指向相关刺激时发生增强的活动，而当注意力远离无关刺激时发生抑制的活动[Gazzaley，A.，库尼，J.，McEhrman，K.，奈特，R.T.，和D 'Esposito，M. J·科恩Neurosci. 17，507-517]。我们使用功能磁共振成像来测试是否差异WM性能，降低响应时间的延迟识别任务，与放大的增强和抑制效应在视觉关联皮层内的刺激编码。我们的研究结果表明，增强和抑制放大的试验与最高的奖励水平相对于非奖励试验的场景选择性皮层区域。在面孔选择性区域，最高奖赏水平的增强与非奖赏水平的增强具有相似的调节作用，前额叶皮层在高奖赏水平的刺激下也表现出增强的活动。总体而言，这些结果表明，奖励动机可以发挥关键作用，通过自上而下的信号在额叶区域参与WM，以及视觉联想区选择性地处理知觉输入的项目被记住。(c)2007 Elsevier B. V.保留所有权利。
Cognitive performance differs with motivation, but little direct evidence exists regarding the neural mechanisms of the influence of reward motivation on working memory (VIM). We tested the effects of motivation on the top-down control in visual Vim. Encoding relevant stimuli for maintenance, while suppressing inappropriate inputs is considered a core process in cognition. Prior functional magnetic resonance imaging (fMRI) results demonstrated that stimulus-specific visual association cortex serves as a marker of activation differences for task-relevant and task-irrelevant inputs, such that enhanced activity occurs when attention is directed to relevant stimuli and suppressed activity occurs when attention is directed away from irrelevant stimuli [Gazzaley, A., Cooney, J., McEvoy, K., Knight, R.T., and D'Esposito, M. J. Cogn. Neurosci. 17, 507-517]. We used fMRI to test whether differential WM performance, indexed by lowered response times on a delayed-recognition task, was associated with amplification of enhancement and suppression effects during stimulus encoding within visual association cortex. Our results indicate that enhancement and suppression are amplified for trials with the highest reward level relative to non-rewarded trials for a scene-selective cortical region. In a face-selective region, similar modulation of enhancement for the highest reward level relative to non-rewarded trials was found. Prefrontal cortex also showed enhanced activity during high reward trials. Overall these results reveal that reward motivation can play a pivotal role in driving performance through top-down signaling in frontal regions involved in WM, as well as visual association regions selective to processing the perceptual inputs of the items to be remembered. (c) 2007 Elsevier B.V. All rights reserved.