Plasmodium falciparum and Schistosoma mansoni coinfection and the side benefit of artemether-lumefantrine in malaria patients
Plasmodium falciparum and Schistosoma mansoni coinfection and the side benefit of artemether-lumefantrine in malaria patients
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DOI：
10.3855/jidc.2658
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发表时间：
2013-06-01
影响因子：
1.9
通讯作者：
Habtewold, Abiy
中科院分区：
文献类型：
--
作者：
Abay, Solomon M.;Tilahun, Mulugeta;Habtewold, Abiy
简介：疟疾和血吸虫病的分布在热带环境中，特别是在撒哈拉以南非洲，有很大的地理重叠。世界上这一地区目前承担着这些疾病估计全球负担的85%以上。研究表明，用于治疗疟疾的青蒿素衍生物也具有抗疟原虫作用。本研究旨在探讨疟疾，血吸虫病合并感染的程度和蒿甲醚-苯芴醇的抗寄生虫作用时，管理治疗恶性疟Kemise，东北Ethiopia.Methodology：粪便样本收集152例经显微镜确诊的疟疾患者和诊断血吸虫病治疗前使用加藤-卡茨技术。结果：152例疟疾患者中合并血吸虫感染者28例，占18.4%（n = 152）。所有28例合并感染患者在治疗后4周粪便中曼氏血吸虫虫卵均为阴性。合并感染的程度与年龄、性别、文化程度有关。蒿甲醚-本芴醇治疗后治愈率和减卵率均为100%。蒿甲醚-苯芴醇对S.合并感染患者中的曼森氏菌。然而，为了更好地了解蒿甲醚-本芴醇对不同强度的疟原虫感染的疗效，需要进行多中心和随机试验。
Introduction: The distribution of both malaria and schistosomiasis exhibits a large geographical overlap in tropical environments, particularly in sub-Saharan Africa. This part of the world currently harbours more than 85% of the estimated global burden of these diseases. Studies showed that artemisinin derivatives used for the treatment of malaria also have an antischistosomal effect. This study aimed to investigate the extent of malaria-schistosomiasis co-infection and the antischistosomal effect of artemether-lumefantrine when administered to treat falciparum malaria in Kemise, Northeast Ethiopia.Methodology: Stool samples were collected from 152 microscopically confirmed malaria patients and diagnosed for schistosomiasis using the Kato-Katz technique before treatment. The schistosomiasis cure rate and egg reduction were determined in co-infected patients, who were treated with artemether-lumefantrine,.Results: Twenty-eight out of 152 malaria patients were co-infected (18.4%, n = 152) with schistosomiasis. All 28 co-infected patients were found stool-negative for Schistosoma mansoni eggs four weeks after treatment. The extent of co-infection was associated with age, sex and educational level. Cure rate and egg reduction rate following the treatment of artemether-lumefantrine were 100%.Conclusion: The co-infection rate was associated with patient characteristics. Artemether-lumefantrine was effective against S. mansoni in co-infected patient. Multicenter and randomized trials, however, are needed for a better understanding of the efficacy of artemether-lumefantrine against schistosome infection with ranges of intensity.