Fluoxetine disrupts food intake and estrous cyclicity in Fischer female rats.
Fluoxetine disrupts food intake and estrous cyclicity in Fischer female rats.
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氟西汀会扰乱费舍尔雌性大鼠的食物摄入和动情周期。
DOI：
10.1016/j.brainres.2005.12.033
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Grossie,Bruce
中科院分区：
文献类型：
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作者：
Uphouse,Lynda;Hensler,JulieG;Sarkar,Jhimly;Grossie,Bruce
成年、定期骑行的雌性Fischer大鼠每日注射氟西汀10 mg/kg，连续12~23天。在第一个实验中，每天监测体重和阴道涂片。氟西汀治疗后24小时内体重减轻。氟西汀治疗还延长了发情周期，降低了血孕酮水平，并消除了前凸行为。在第二个实验中，检测了体重和食物摄入量，并包括了一对喂食组，以确定氟西汀引起的厌食症是否对动情周期的干扰起到了作用。在配对喂养的大鼠中，也存在类似于氟西汀治疗的效果。这些结果表明，氟西汀的厌食特性可能会扰乱女性正常的内分泌循环，这种扰乱可能与性行为和动机的减少有关。然而，当氟西汀治疗的持续时间超过16至17天时，氟西汀治疗的雌性大鼠重新启动阴道周期性，并显示出正常性接受的证据。相比之下，配对饲养的母牛的发情周期仍然被打乱。因此，在氟西汀治疗期间，限制食物摄入似乎有助于扰乱发情周期和消除性接受性。然而，与长期服用氟西汀相关的5-羟色胺能系统的代偿性改变可能有助于氟西汀治疗的动物动情周期和性接受能力的逐渐恢复。
Adult, regularly cycling female Fischer rats were injected daily with 10 mg/kg fluoxetine for 12–23 days. In the first experiment, body weight and vaginal smears were monitored daily. Fluoxetine treatment reduced body weight within the first 24 h of treatment. Fluoxetine treatment also elongated the estrous cycle, reduced blood levels of progesterone, and eliminated lordosis behavior. In the second experiment, body weight and food intake were examined and a pair-fed group was included to determine if fluoxetine-induced anorexia contributed to the disturbance of the estrous cycle. In pair-fed rats, effects similar to fluoxetine treatment were present. These results lead to the suggestion that fluoxetine's anorectic properties could disrupt the female's normal endocrine cyclicity and that this disruption could be relevant to the reduction in sexual behavior and motivation. However, when the duration of fluoxetine treatment was extended beyond 16 to 17 days, fluoxetine-treated female rats reinitiated vaginal cyclicity and showed evidence of normal sexual receptivity. In contrast, the estrous cycles of their pair-fed counterparts remained disrupted. Thus, restricted food intake appears to contribute to the disruption of the estrous cycle and elimination of sexual receptivity during fluoxetine treatment. However, compensatory changes in the serotonergic system that are associated with chronic fluoxetine administration may contribute to the gradual recovery of estrous cyclicity and sexual receptivity of the fluoxetine-treated animals.