α-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy
α-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy
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DOI：
10.1016/s0304-3940(98)00407-8
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发表时间：
1998-06-19
影响因子：
2.5
通讯作者：
Takahashi, H
中科院分区：
文献类型：
--
作者：
Wakabayashi, K;Yoshimoto, M;Takahashi, H
帕金森氏病（PD）中的路易体与α-突触核蛋白的抗体具有强烈的免疫反应性，α-突触核蛋白在该疾病的一些家族性病例中发生突变。我们进行了免疫组织化学检查的大脑多系统萎缩（MSA）患者使用抗α-突触核蛋白抗体。强α-突触核蛋白免疫反应性被发现在胶质细胞胞质包涵体（GCI），这是少突胶质细胞的起源，只发生在MSA。在黑质、脑桥和下橄榄核以及齿状筋膜中也偶尔发现α-突触核蛋白免疫反应神经元胞质内含物（NCIs）。这些发现表明，α-突触核蛋白也是MSA中GCI和NCI的主要组分，并强烈表明α-突触核蛋白聚集是某些神经退行性疾病（包括PD和MSA）中的常见过程。(C)1998由Elsevier Science爱尔兰有限公司出版。保留所有权利。
Lewy bodies in Parkinson's disease (PD) are strongly immunoreactive with antibodies against alpha-synuclein, which is mutated in some familial cases of the disease. We carried out immunohistochemical examinations of the brains of multiple system atrophy (MSA) patients using anti-alpha-synuclein antibodies. Strong a-synuclein immunoreactivity was found in glial cytoplasmic inclusions (GCIs), which are of oligodendroglial origin and occur exclusively in MSA. alpha-Synuclein-immunoreactive neuronal cytoplasmic inclusions (NCIs) were also found occasionally in the substantia nigra, pontine and inferior olivary nuclei, and dentate fascia. These findings indicate that alpha-synuclein is also a major component of GCIs and NCIs in MSA and strongly suggest that alpha-synuclein aggregation is a common process in certain neurodegenerative diseases, including PD and MSA. (C) 1998 Published by Elsevier Science Ireland Ltd. All rights reserved.