Prevention of Major Depression
Prevention of Major Depression
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DOI：
10.1146/annurev-clinpsy-033109-132040
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发表时间：
2010-01-01
期刊：
影响因子：
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通讯作者：
Leykin, Yan
中科院分区：
文献类型：
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作者：
Munoz, Ricardo F.;Cuijpers, Pim;Leykin, Yan
在 20 世纪 80 年代之前，还没有进行过随机对照试验来测试是否可以预防重度抑郁发作。在过去的 30 年里，多项试验报告在降低重度抑郁发作的发生率（新病例数）方面取得了成功。这些研究表明重度抑郁症是可以预防的。鉴于重度抑郁症造成的巨大疾病负担，现在是时候进行大量系统性努力来复制这些研究、开展多中心试验并广泛传播被证明有效的预防干预措施。本综述探讨了治疗和预防试验之间的概念和实践差异，以及识别重度抑郁发作短期高风险群体的重要性，以使预防试验可行。我们还列出了迄今为止已进行的随机对照预防试验，并讨论了超越传统面对面干预措施限制的预防干预措施的必要性。
Before the 1980s, no randomized controlled trials had been carried out to test whether major depressive episodes could be prevented. In the past 30 years, several trials have reported success in reducing the incidence (the number of new cases) of major depressive episodes. These studies suggest that major depression can be prevented. Given the large burden of disease caused by major depression, it is time for substantial systematic efforts to replicate these studies, carry out multisite trials, and widely disseminate prevention interventions found to be effective. The present review examines the conceptual and practical differences between treatment and prevention trials and the importance of identifying groups at high short-term risk for major depressive episodes to make prevention trials feasible. We also list the randomized controlled prevention trials that have been carried out to date and discuss the need for prevention interventions that go beyond the limits of traditional face-to-face interventions.