Regulation of life-span by germ-line stem cells in Caenorhabditis elegans
Regulation of life-span by germ-line stem cells in Caenorhabditis elegans
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DOI：
10.1126/science.1065768
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发表时间：
2002-01-18
期刊：
影响因子：
56.9
通讯作者：
Kenyon, C
中科院分区：
文献类型：
--
作者：
Arantes-Oliveira, N;Apfeld, J;Kenyon, C
线虫的生殖系影响寿命;当生殖系前体细胞被去除时，寿命显著增加。我们发现精子、卵母细胞和减数分裂前体细胞都不对这种效应负责。相反，寿命受到生殖系干细胞增殖的影响。这些细胞，以及下游转录调节因子，在成人中起作用以影响衰老，表明衰老过程在成年期间保持可塑性。我们认为，生殖系干细胞通过影响促进长寿的类固醇激素的产生或对类固醇激素的反应来影响寿命。
The germ line of the nematode Caenorhabditis elegans influences life-span; when the germ-line precursor cells are removed, life-span is increased dramatically. We find that neither sperm, nor oocytes, nor meiotic precursor cells are responsible for this effect. Rather life-span is influenced by the proliferating germ-line stem cells. These cells, as well as a downstream transcriptional regulator, act in the adult to influence aging, indicating that the aging process remains plastic during adulthood. We propose that the germ-line stem cells affect life-span by influencing the production of, or the response to, a steroid hormone that promotes longevity.