The effects of d-amphetamine on intake of food and a sweet fluid containing cocaine
The effects of d-amphetamine on intake of food and a sweet fluid containing cocaine
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DOI：
10.1016/s0091-3057(98)00217-2
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发表时间：
1999-03-01
影响因子：
3.6
通讯作者：
Evans, SM
中科院分区：
文献类型：
--
作者：
Foltin, RW;Evans, SM
使用实验室动物程序来测量强化的两个方面（自我给药和位置偏好），5只成年恒河猴分别生活在3个室中：口服可卡因自我给药（0.26mg/kg/递送可卡因盐酸盐在甜味液体中）特异于一端室，食物自我给药特异于另一端室，并且在中间腔室中没有可用的食物线索或流体线索。在整个10小时的实验日，猴子经历了多种食物，可卡因和选择（食物与甜可卡因流体），会话。口服右旋苯丙胺（AMPH; 0.5-1.5 mg/kg）或安慰剂，以确定这种厌食药物是否会不同地改变食物和甜可卡因流体的自我给药。此外，当指示商品可用性的刺激线索不存在（位置偏好）时，确定AMPH对猴子在每个腔室中花费的时间长度的影响。AMPH产生的剂量依赖性减少食物和可卡因自我管理，而不影响选择行为。AMPH还增加了猴子在食物室中度过的时间长度，即使没有刺激指示食物可用性。这些结果表明，自我管理和位置偏好的强化措施之间的关系是不完全一致的。目前的程序可能证明是有用的，在研究这两种措施的加固。(C)1999 Elsevier Science Inc.
Using a laboratory animal procedure designed to measure two aspects of reinforcement (self-administration and location preference), five adult rhesus monkeys each lived in three chambers: oral cocaine self-administration (0.26 mg/kg/delivery cocaine hydrochloride in a sweet fluid) was specific to one end chamber, food self-administration was specific to the other end chamber, and no food cues or fluid cues were available in the middle chamber. Throughout the 10-h experimental day monkeys experienced multiple food, cocaine, and choice (food vs. sweet cocaine fluid), sessions. Oral d-amphetamine (AMPH; 0.5-1.5 mg/kg) or placebo was administered before the sessions to determine if this anorectic drug would differentially alter food and sweet cocaine fluid self-administration. Further, the effects of AMPH on the length of time a monkey spent in each chamber, when the stimulus cues indicating commodity availability were not present (Location preference) were determined. AMPH produced dose-dependent decreases in both food and cocaine self-administration without affecting choice behavior. AMPH also increased the length of time monkeys spent in the food chamber, even when no stimuli indicating food availability were present. These results indicate that the relationship between self-administration and location preference measures of reinforcement is not completely concordant. The current procedure may prove useful in studying these two measures of reinforcement. (C) 1999 Elsevier Science Inc.