Computer Simulation of the Mechanical Behaviour of Implanted Biodegradable Stents in a Remodelling Artery
Computer Simulation of the Mechanical Behaviour of Implanted Biodegradable Stents in a Remodelling Artery
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DOI：
10.1007/s11837-015-1761-5
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发表时间：
2016-04-01
期刊：
影响因子：
2.6
通讯作者：
Mchugh, Peter E.
中科院分区：
文献类型：
--
作者：
Boland, Enda L.;Grogan, James A.;Mchugh, Peter E.
冠状动脉支架已经彻底改变了冠状动脉疾病的治疗。虽然冠状动脉支架植入术现在相对成熟，但仍然存在重大的科学和技术挑战。最肥沃的技术增长领域之一是可生物降解的支架;在此，一旦最初必要的支架期过去（6-12个月）（格罗甘等人，Acta Biomater 7：3523，2011）并且当动脉已经重塑（包括新内膜的形成）时，就有可能产生将在体内分解的支架。作者基于Abaqus软件（DS-SIMULIA，USA）开发了支架血管成形术计算试验台，能够模拟动脉粥样硬化动脉模型中的支架跟踪、球囊扩张、回缩和体内加载。此外，还开发了一种表面腐蚀模型，用于模拟生物可降解支架的均匀腐蚀和点蚀，并表示支架植入后动脉组织的主动反应，即新生内膜重塑。使用生物可降解支架腐蚀进行的动脉新生内膜重塑模拟表明，支架支柱周围新动脉组织的形成对降解支架的机械性能具有实质性影响。
Coronary stents have revolutionised the treatment of coronary artery disease. While coronary artery stenting is now relatively mature, significant scientific and technological challenges still remain. One of the most fertile technological growth areas is biodegradable stents; here, there is the possibility to generate stents that will break down in the body once the initial necessary scaffolding period is past (6-12 months) (Grogan et al. in Acta Biomater 7:3523, 2011) and when the artery has remodelled (including the formation of neo-intima). A stent angioplasty computational test-bed has been developed by the authors, based on the Abaqus software (DS-SIMULIA, USA), capable of simulating stent tracking, balloon expansion, recoil and in vivo loading in a atherosclerotic artery model. Additionally, a surface corrosion model to simulate uniform and pitting corrosion of biodegradable stents and a representation of the active response of the arterial tissue following stent implantation, i.e. neointimal remodelling, has been developed. The arterial neointimal remodelling simulations with biodegradable stent corrosion demonstrate that the development of new arterial tissue around the stent struts has a substantial effect on the mechanical behaviour of degrading stents.