Increased prevalence of perennial allergic rhinitis in patients with obstructive sleep apnea
Increased prevalence of perennial allergic rhinitis in patients with obstructive sleep apnea
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DOI：
10.1159/000076674
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发表时间：
2004-01-01
期刊：
影响因子：
3.7
通讯作者：
Leuppi, JD
中科院分区：
文献类型：
--
作者：
Canova, CR;Downs, SH;Leuppi, JD
背景：鼻呼吸障碍是阻塞性睡眠呼吸暂停综合征（OSAS）的一个危险因素。目的：本研究的目的是确定常年性过敏原的特应性和常年性变应性鼻炎的存在是否是OSAS的危险因素。研究方法：在一项病例对照研究中，我们比较了OSAS患者对常年性过敏原和常年性变应性鼻炎的比例与慢性阻塞性肺疾病（COPD）患者的比例。从瑞士的一家医院门诊选择了72名OSAS患者（平均年龄60.7岁; 79.4%为男性）和44名COPD患者（平均年龄63.6岁; 88.6%为男性）。所有患者完成了呼吸道症状问卷调查，进行肺功能测定，并进行了过敏性皮肤点刺试验。结果如下：OSAS患者明显比COPD患者重（BMI 32.4 +/-（SD）6.6 vs. 29.2 +/- 6.6 kg/m2，p = 0.04），肺功能比COPD患者好（FEV1%预测值91.3 +/- 19.2 vs. 51.6 +/-18.9%，p < 0.001）。与COPD患者相比，OSAS患者更容易对常年性过敏原过敏，如屋尘螨（23.6%对4.5%，p = 0.009）和狗（18%对4.5%，p = 0.04）。11%的OSAS患者报告了常年性变应性鼻炎（常年有鼻部问题[鼻塞和/或流鼻涕和/或打喷嚏]，并且对至少一种常年性过敏原过敏），但仅2.3%的COPD患者报告了常年性变应性鼻炎（p = 0.15）。结论：我们的结论是，受试者与阻塞性睡眠呼吸暂停综合征可能有一个增加的风险是过敏的常年性过敏原，并患有常年性鼻炎。在临床情况下，意识到这种风险可能具有重要的考虑因素。版权所有（C）2004 S. Karger AG，巴塞尔。
Background: Impaired nasal breathing is a risk factor for obstructive sleep apnea syndrome (OSAS). Objectives: The aim of this study was to determine whether atopy to perennial allergens and existence of perennial allergic rhinitis was a risk factor for OSAS. Methods: In a case-control study, we compared the proportions of OSAS patients with atopy to perennial allergens and perennial allergic rhinitis to the proportions in patients with chronic obstructive pulmonary disease (COPD). Seventy-two OSAS patients (mean age 60.7 years; 79.4% male) and 44 COPD patients (mean age 63.6 years; 88.6% male) were selected from a hospital outpatients' clinic in Switzerland. All patients completed a respiratory symptom questionnaire, performed spirometry and had a skin prick test for atopy. Results: OSAS patients were significantly heavier than COPD patients (BMI 32.4 +/- (SD) 6.6 vs. 29.2 +/- 6.6 kg/m(2), p = 0.04) and had a better lung function than COPD patients (FEV1% predicted 91.3 +/- 19.2 vs. 51.6 +/- 18.9%, p < 0.001). Patients with OSAS were more likely to be sensitized to perennial allergens such as house dust mite (23.6 vs. 4.5%, p = 0.009) and dog (18 vs. 4.5%, p = 0.04) than the COPD patients. Perennial allergic rhinitis ( having nose problems [ nasal obstruction and/or runny nose and/or sneezing] all year and being atopic to at least one perennial allergen) was reported in 11% of OSAS patients but in only 2.3% of COPD patients (p = 0.15). Conclusion: We conclude that subjects with OSAS may have an increased risk of being allergic to perennial allergens and suffer from perennial rhinitis. Awareness of this risk may have important consideration in the clinical situation. Copyright (C) 2004 S. Karger AG, Basel.