Metalated aziridines for cross-coupling with aryl and alkenyl halides via palladium catalysis.
Metalated aziridines for cross-coupling with aryl and alkenyl halides via palladium catalysis.
复制标题
金属化氮丙啶通过钯催化与芳基卤化物和烯基卤化物交叉偶联。
DOI：
10.1021/ol101904a
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发表时间：
2010
期刊：
影响因子：
5.2
通讯作者：
Vedejs,Edwin
中科院分区：
文献类型：
--
作者：
Nelson,JohnM;Vedejs,Edwin
已经证明了氮丙啶基氯化锌中间体与烯基和芳基卤化物的钯催化偶联。该方法提供了具有氮丙啶立体化学保留的产物。偶联过程的效用说明在合成相关的结构tol-furanomycin。
The palladium-catalyzed coupling of an aziridinylzinc chloride intermediate with alkenyl and aryl halides has been demonstrated. The method provides products with retention of aziridine stereochemistry. The utility of the coupling procedure is illustrated in the synthesis of structures related tol-furanomycin.