Glomerular size and structure in diabetes mellitus. I. Early abnormalities.
Glomerular size and structure in diabetes mellitus. I. Early abnormalities.
复制标题
糖尿病肾小球的大小和结构。
作者：
R. Osterby;H. Gundersen
在青少年糖尿病患者发病时和疾病持续一到六年后，对肾小球簇及其组成部分的体积进行了估计。新诊断的糖尿病患者的肾小球簇增大。在这些患者中，个体毛细血管管腔和个体肾小球细胞的体积均增大，而细胞数量没有变化。尽管糖尿病患者在患病几年后可以看到部分正常化，但这些患者的毛细血管容积仍然升高。讨论了这些发现与有据可查的糖尿病患者肾小球滤过率升高之间可能的关系。有人认为，形态和功能变化背后的机制是压力引起的毛细血管壁展开或毛细血管壁面积增加，但目前的研究不允许对这些可能性进行区分。
The volume of the glomerular tuft and its components was estimated in juvenile diabetics at onset and after one to six year's duration of the disease. An enlargement of the glomerular tuft was demonstrated in the newly diagnosed diabetics. In these patients the volume of both the individual capillary lumina and of the individual glomerular cells was enlarged, whereas the number of cells was unchanged. Although a partial normalization is seen in diabetics after a few years' disease, such patients still have an elevated capillary volume. The possible relationship between these findings and the well-documented elevation of the glomerular filtration rate in diabetics is discussed. It is suggested that the mechanism behind the morphological and functional changes is either a pressure-induced unfolding of the capillary wall or an increase of the capillary wall area, but the present study permits no distinction between these possibilities.