An adverse lipoprotein phenotype-hypertriglyceridaemic hyperapolipoprotein B - and the long-term risk of type 2 diabetes: a prospective, longitudinal, observational cohort study
An adverse lipoprotein phenotype-hypertriglyceridaemic hyperapolipoprotein B - and the long-term risk of type 2 diabetes: a prospective, longitudinal, observational cohort study
复制标题
DOI：
10.1016/s2666-7568(22)00079-4
复制
发表时间：
2022-05-01
影响因子：
13.1
通讯作者：
Sniderman, Allan D.
中科院分区：
文献类型：
--
作者：
Pencina, Karol M.;Pencina, Michael J.;Sniderman, Allan D.
背景 本研究调查了高甘油三酯血症高载脂蛋白 B（高甘油三酯、高载脂蛋白 B [apoB]、低 LDL 胆固醇与 apoB 比率和低 HDL 胆固醇）患者的新发糖尿病风险。目的是确定这种脂蛋白表型是否识别出未来 20 年内患糖尿病高风险的大量群体。 方法 在这项前瞻性、纵向、观察性队列研究中，我们使用了 Framingham Offspring 队列（在美国马萨诸塞州弗雷明汉招募）的数据。参与者年龄为 40-69 岁，在 1987 年 4 月至 1991 年 11 月期间进行的基线检查中没有糖尿病和心血管疾病，并随访至 2014 年 3 月。使用对年龄和性别、腰围和空腹血糖进行分层调整的 Cox 比例风险回归来模拟每个脂质标志物与糖尿病发生率之间的关系，以及高甘油三酯血症 hyperapoB（定义为大于样本中值的值）之间的关系。甘油三酯和 apoB，以及低于 HDL 胆固醇和 LDL 胆固醇与 apoB 比率的中位数）和糖尿病事件。结果 在完成基线检查的 3446 名 40-69 岁个体中，2515 名参与者符合资格并纳入所有分析。在中位 21.1 年 (IQR 11.1-23-1) 的随访期间，402 人 (16.0%) 罹患糖尿病。年龄 (p=0.032)、腰围 (p
Background This study examines the risk of new-onset diabetes in patients with hypertriglyceridaemic hyperapolipoprotein B (high triglycerides, high apolipoprotein B [apoB], low LDL cholesterol to apoB ratio, and low HDL cholesterol). The aim was to establish whether this lipoprotein phenotype identified a substantial group at high risk of developing diabetes over the next 20 years.Methods In this prospective, longitudinal, observational cohort study, we used data from the Framingham Offspring cohort (recruited in Framingham, MA, USA). Participants were aged 40-69 years and free of diabetes and cardiovascular disease at a baseline examination done between April, 1987, and November, 1991, and were followed up until March, 2014. Cox proportional hazards regression with hierarchical adjustment for age and sex, waist circumference, and fasting blood glucose were used to model the relationship between each lipid marker and incident diabetes, as well as the relationship between hypertriglyceridaemic hyperapoB (defined as values greater than sample medians of triglycerides and apoB, and less than medians of HDL cholesterol and LDL cholesterol to apoB ratio) and incident diabetes.Findings Of 3446 individuals aged 40-69 years who completed baseline examination, 2515 participants were eligible and included in all analyses. During median 21.1 years (IQR 11.1-23-1) of follow-up, 402 (16.0%) individuals developed diabetes. Age (p=0.032), waist circumference (p