PBK/TOPK Expression Predicts Prognosis in Oral Cancer.
PBK/TOPK Expression Predicts Prognosis in Oral Cancer.
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DOI：
10.3390/ijms17071007
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发表时间：
2016-06-24
影响因子：
5.6
通讯作者：
Chou MC
中科院分区：
文献类型：
--
作者：
Chang CF;Chen SL;Sung WW;Hsieh MJ;Hsu HT;Chen LH;Chen MK;Ko JL;Chen CJ;Chou MC
口腔癌是一种常见的恶性肿瘤，预后较差。我们评估了PBK/TOPK （pdz结合激酶/T-LAK细胞源蛋白激酶）在口腔癌中的表达及其预后意义。通过免疫组织化学染色检测287例口腔癌患者标本中PBK/TOPK的表达。分析PBK/TOPK表达与临床病理特征的关系。通过Kaplan-Meier分析和Cox比例风险模型确定PBK/TOPK对总生存期的预后价值。高PBK/TOPK表达水平与较长的总生存期相关。PBK/TOPK表达在年轻患者（p < 0.05）、吸烟习惯患者（p < 0.05）和晚期疾病患者（p < 0.05）中具有显著的预后作用。我们的研究结果表明，PBK/TOPK在口腔癌中的表达增强。PBK/TOPK的高表达，无论是单独表达还是根据临床病理特征分亚组表达，都可能作为口腔癌患者预后的有利标志。
Oral cancer is a common cancer with poor prognosis. We evaluated the expression of PBK/TOPK (PDZ-binding kinase/T-LAK cell-originated protein kinase) and its prognostic significance in oral cancer. PBK/TOPK expression was measured by immunohistochemical staining of samples from 287 patients with oral cancer. The association between PBK/TOPK expression and clinicopathological features was analyzed. The prognostic value of PBK/TOPK for overall survival was determined by Kaplan-Meier analysis and Cox proportional hazard models. A high PBK/TOPK expression level was correlated with long overall survival. The prognostic role of PBK/TOPK expression was significant in young patients (p < 0.05), patients with smoking habits (p < 0.05), and late stage disease (p < 0.05). Our results suggest that PBK/TOPK expression is enhanced in oral cancer. High PBK/TOPK expression, either alone or in subgroups according to clinicopathological features, may serve as a favorable prognostic marker for patients with oral cancer.