Experimental and clinical performance of porous tantalum in orthopedic surgery
Experimental and clinical performance of porous tantalum in orthopedic surgery
复制标题
DOI：
10.1016/j.biomaterials.2006.04.041
复制
发表时间：
2006-09-01
期刊：
影响因子：
14
通讯作者：
Jacobs, Joshua J.
中科院分区：
文献类型：
--
作者：
Levine, Brett Russell;Sporer, Scott;Jacobs, Joshua J.
多孔钽是一种新型的低模数金属，具有类似松质骨的特征外观，目前可用于多种骨科应用(髋关节和膝关节成形术、脊柱手术和骨移植替代品)。重复的十二面体的开孔结构是通过碳气相沉积/渗透商业纯钽到玻璃碳支架上而产生的。这种过渡金属保持了几种有趣的生物材料特性，包括：高体积孔隙率(70-80%)、低弹性模数(3兆帕)和高摩擦特性。钽具有良好的生物相容性，在体内使用是安全的，这一点从它在起搏电极、颅骨成形术钢板和作为不透射线标志物的历史和当前使用中得到了证明。多孔钽的生物活性和生物相容性源于它能够形成自钝化的表面氧化层。该表层可在体内形成类骨磷灰石涂层，并提供优异的骨和纤维内生长特性，从而实现快速和实质性的骨和软组织附着。钽-软骨细胞复合材料在体外已经取得了成功的早期结果，并可能。提供了一个选项，在未来的联合重新铺装。多孔钽的发展还处于发展的早期阶段，下面是对其生物材料特性和在骨科手术中的应用的综述。(C)2006爱思唯尔有限公司。保留所有权利。
Porous tantalum, a new low modulus metal with a characteristic appearance similar to cancellous bone, is currently available for use in several orthopedic applications (hip and knee arthroplasty, spine surgery, and bone graft substitute). The open-cell structure of repeating dodecahedrons is produced via carbon vapor deposition/infiltration of commercially pure tantalum onto a vitreous carbon scaffolding. This transition metal maintains several interesting biomaterial properties, including: a high volumetric porosity (70-80%), low modulus of elasticity (3 MPa), and high frictional characteristics. Tantalum has excellent biocompatibility and is safe to use in vivo as evidenced by its historical and current use in pacemaker electrodes, cranioplasty plates and as radiopaque markers. The bioactivity and biocompatibility of porous tantalum stems from its ability to form a self-passivating surface oxide layer. This surface layer leads to the formation of a bone-like apatite coating in vivo and affords excellent bone and fibrous in-growth properties allowing for rapid and substantial bone and soft tissue attachment. Tantalum-chondrocyte composites have yielded successful early results in vitro and may. afford an option for joint resurfacing in the future. The development of porous tantalum is in its early stages of evolution and the following represents a review of its biomaterial properties and applications in orthopedic surgery. (c) 2006 Elsevier Ltd. All rights reserved.