Activation of spinal serotonin2A/2C receptors augments nociceptive responses in the rat
Activation of spinal serotonin2A/2C receptors augments nociceptive responses in the rat
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DOI：
10.1016/s0006-8993(01)02652-x
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发表时间：
2001-08-10
期刊：
影响因子：
2.9
通讯作者：
Hole, K
中科院分区：
文献类型：
--
作者：
Kjorsvik, A;Tjolsen, A;Hole, K
本实验研究了脊髓5-HT2A/2C受体在脊髓伤害性信息传递中的作用。福尔马林实验前立即鞘内注射5-羟色胺A/2C激动剂(+/-)-1-(2，5-dimethoxy-4-iodophenyl)-2-aminopropane和拮抗剂酒石酸酮坦丝林。脊髓5-HT2A/2C受体的激活增加了早期和晚期的痛样行为反应。结果支持脊髓5-HT2A/2C受体增强外周炎症引起的脊髓伤害性传入冲动的假说。(C)2001年爱思唯尔科学公司。版权所有。
The role of spinal 5-HT2A/2C receptors in the regulation of spinal nociceptive transmission was studied. The 5-HT2A/2C agonist (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and the antagonist ketanserin tartrate were administered intrathecally immediately before the formalin test. Activation of spinal 5-HT2A/2C receptors increased the pain-like behavioural response in both the early and late phases. The findings support the hypothesis that spinal 5-HT2A/2C receptors augment the spinal afferent nociceptive impulses induced by peripheral inflammation. (C) 2001 Elsevier Science BY. All rights reserved.