Molecular chaperones and neurodegenerative diseases.
Molecular chaperones and neurodegenerative diseases.
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DOI：
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发表时间：
2006-03
影响因子：
5.6
通讯作者：
You-e Yan;Hui Wang;M. Fan
中科院分区：
文献类型：
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作者：
You-e Yan;Hui Wang;M. Fan
Neurodegenerative diseases are characterized by the accumulation of intracellular or extracellular protein aggregates that result from conformational changes in proteins. These diseases may result from an imbalance between the production of misfolded proteins and normal chaperone capacity. Molecular chaperones provide a first line of defence against misfolded, aggregation-prone proteins and are, therefore, promising therapeutic targets for neurodegenerative diseases.
