Autistic-like behavior in CHARGE syndrome
Autistic-like behavior in CHARGE syndrome
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DOI：
10.1002/ajmg.a.30545
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发表时间：
2005-03-15
影响因子：
2
通讯作者：
Parker, KR
中科院分区：
文献类型：
--
作者：
Hartshorne, TS;Grialou, TL;Parker, KR
患有 CHARGE 综合征的儿童经常表现出中度至重度的行为困难，并且经常被诊断患有强迫症、注意力缺陷障碍、抽动秽语综合征和自闭症。 Hartshorne 和 Cypher (2004) 对全世界 100 名 CHARGE 儿童的父母进行了调查，并证实了与这些疾病相关的行为的普遍性。他们还发现了聋盲人的典型行为。本研究探讨了 CHARGE 儿童的类似自闭症行为是否与聋盲儿童、自闭症儿童或 CHARGE 特有儿童的行为更相似。包括自闭症行为检查表 (ABC) 在内的调查已邮寄给 204 名 CHARGE 儿童的家庭，并退回了 160 份可用调查 (78%)。 CHARGE 儿童的 ABC 总分与自闭症儿童和聋盲儿童的标准分数显着不同。然而，CHARGE 的方差大于正常组，27.5% 的 CHARGE 患者可被归类为自闭症。 CHARGE 组的子量表得分模式与其他规范组不同。 (C) 2005 Wiley-Liss, Inc.
Children with CHARGE syndrome frequently exhibit moderate to severe behavior difficulties, and are often diagnosed with obsessive-compulsive disorder, attention deficit disorder, Tourette syndrome, and autism. Hartshorne and Cypher (2004) surveyed parents of 100 children with CHARGE worldwide and confirmed the prevalence of behaviors that are associated with these disorders. They also found behaviors that could be described as typical of persons who are deafblind. The present study examined whether the autistic-like behaviors of children with CHARGE are more similar to those of children who are deafblind, to those of children who are autistic or are unique to CHARGE. Surveys including the Autism Behavior Checklist (ABC) were mailed to families of 204 children with CHARGE, and 160 usable surveys were returned (78%). Total scores on the ABC for children with CHARGE were significantly different from the norms for those with autism, and those who were deafblind. However, the variance for CHARGE was larger than for the normative groups, and 27.5% of those with CHARGE could be classified as autistic. The pattern of subscale scores for those with CHARGE differed from the other normative groups. (C) 2005 Wiley-Liss, Inc.