A STUDY OF THE CONTRIBUTION OF HIPPOCAMPAL ACCUMBENS SUBPALLIDAL PROJECTIONS TO LOCOMOTOR-ACTIVITY
A STUDY OF THE CONTRIBUTION OF HIPPOCAMPAL ACCUMBENS SUBPALLIDAL PROJECTIONS TO LOCOMOTOR-ACTIVITY
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DOI：
10.1016/s0163-1047(84)90412-6
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发表时间：
1984-01-01
期刊：
影响因子：
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通讯作者：
NIELSEN, M
中科院分区：
文献类型：
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作者：
MOGENSON, GJ;NIELSEN, M
将胆碱能激动剂卡巴胆碱单侧注射到[大鼠]海马齿状回中，可显著增加自动开阔仪中记录的运动活动。将谷氨酸拮抗剂注入同侧伏隔核时，这种方式引起的过度活动明显减少。将GABA注射到同侧苍白球下区域也可以减少向齿状回注射卡巴胆碱引起的过度活动。当将这些化合物分别注射到对侧伏隔核和苍白球下区时，卡巴胆碱诱发的运动活动几乎没有减少。因此，从海马区到伏隔区再到苍白球下区的神经通路可能参与了运动活动。
Locomotor activity recorded in an automated open-field apparatus was increased substantially by unilateral injections of carbachol, a cholinergic agonist, into the dentate gyrus of the [rat] hippocampus. Hyperactivity elicited in this way was reduced significantly when glutamate antagonists were injected into the ipsilateral nucleus accumbens. Injecting GABA into the ipsilateral subpallidal region also reduced the hyperactivity from injections of carbachol into the dentate gyrus. When these compounds were injected into the contralateral accumbens and subpallidal region, respectively, there was little or no reduction in the carbachol-elicited locomotor activity. Thus, neural pathways from hippocampus to accumbens to subpallidal region may contribute to locomotor activity.