T-bet+ lymphocytes infiltration as an independent better prognostic indicator for triple-negative breast cancer
T-bet+ lymphocytes infiltration as an independent better prognostic indicator for triple-negative breast cancer
复制标题
T-bet阳性淋巴细胞浸润作为三阴性乳腺癌的一个独立的较好预后指标
DOI：
10.1007/s10549-019-05256-2
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发表时间：
2019-08-01
影响因子：
3.8
通讯作者：
Nakamura, Masafumi
中科院分区：
文献类型：
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作者：
Mori, Hitomi;Kubo, Makoto;Nakamura, Masafumi
目的T-box转录因子21（T-bet）是T细胞受体激活的主要调节因子。在这项研究中，我们专注于T-bet和检查活化T细胞的功能。MethodsThis study includes 242 patients with primary triple-negative breast cancer（TNBC）who performed removal without neoadjuvant chemotherapy between January 2004 and December 2014.结果242例TNBC中，127例（52.5%）肿瘤组织中CD 8阳性表达，67例（27.7%）肿瘤组织中T-bet阳性表达。T-bet表达与CD 8表达显著相关（p
PurposeT-box transcription factor 21 (T-bet), which is the master regulator of effector T-cell activation, is derived by stimulation of T-cell receptors. In this study, we focused on T-bet and examined the function of activated T cells.MethodsThis study included 242 patients with primary triple-negative breast cancer (TNBC) who underwent resection without neoadjuvant chemotherapy between January 2004 and December 2014. The immunohistochemistry scoring for CD8 and T-bet expression on tumor-infiltrating lymphocytes (TILs) was defined as30 per 6.25x10(-3)mm(2).ResultsOf the 242 TNBC cases, CD8 was positively expressed in 127 (52.5%) tumors, and T-bet was positively expressed in 67 (27.7%) tumors. T-bet expression was significantly correlated with CD8 expression (p