Reduced Vasoreactivity in Corpus Cavernosum of the Akita Mouse
Reduced Vasoreactivity in Corpus Cavernosum of the Akita Mouse
复制标题
秋田小鼠海绵体血管反应性降低
DOI：
10.2164/jandrol.110.010223
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发表时间：
2010-11-01
影响因子：
--
通讯作者：
Zhang, Xiaoyang
中科院分区：
文献类型：
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作者：
Jia, Lijing;Xie, Donghua;Zhang, Xiaoyang
糖尿病（DM）是勃起功能障碍（艾德）的重要危险因素。我们试图研究秋田人血管反应性的性质和机制（Ins 2 [WT/C96 Y]）小鼠，一种遗传性非肥胖1型糖尿病的模型，其重现人1型糖尿病8只野生型（WT）小鼠（组1）和8只秋田小鼠（组2）本研究使用的是收集的尸体组织，并通过血管内皮生长因子（VEGF）和环磷酸鸟苷（cGMP）的等长张力研究来研究内皮依赖性和内皮非依赖性血管反应性。采用酶联免疫吸附试验（ELISA）秋田小鼠的体组织中内皮依赖性和内皮非依赖性血管反应性cGMP和VEGF显著降低。来自秋田小鼠的体组织显示出在人类中发现的许多主要功能和生化变化该模型可作为一个有价值的工具，以促进我们对糖尿病在艾德发病机制中所起作用的理解。
Diabetes Mellitus (DM) is an important risk factor of erectile dysfunction (ED) We sought to investigate the nature and mechanism of the vasoreactivity in Akita (Ins2 [WT/C96Y]) mice a model of genetic nonobese Type 1 diabetes that recapitulates human Type 1 diabetes Eight wild type (WT) mice (group 1) and 8 Akita mice (group 2) were used for this study Corporal tissues were harvested and studied for endothelium dependent and endothelium independent vasoreactivities by isometric tension study levels of vascular endothelial growth factor (VEGF) and cyclic guanosine monophosphate (cGMP) were studied with the use of enzyme linked immunosorbent assay (ELISA) Endothelium dependent and endo thelium independent vasoreactivities cGMP and VEGF were significantly decreased in the corporal tissues of Akita mice Corporal tissues from Akita mice demonstrate many of the major functional and biochemical changes found in humans with ED This model could serve as a valuable tool for advancing our understanding of the role DM plays in the pathogenesis of ED