Meta-analytic research of the dose-response relationship between salt intake and risk of heart failure
Meta-analytic research of the dose-response relationship between salt intake and risk of heart failure
复制标题
食盐摄入量与心力衰竭风险剂量反应关系的荟萃分析研究
DOI：
10.1038/s41440-021-00632-2
复制
发表时间：
2021
期刊：
影响因子：
5.4
通讯作者：
Sone H
中科院分区：
文献类型：
--
作者：
Kodama S;Horikawa C;Fujihara K;Hatta M;Takeda Y;Nedachi R;Kato K;Watanabe K;Sone H
心力衰竭（HF）在全球范围内日益流行。高血压和冠心病（CHD）是HF的主要诱因[1]。盐摄入量增加与血压升高有关[2]，冠心病相关死亡率的风险众所周知[3]。据信，限制盐摄入量可降低HF的风险。然而，一些数据与这一信念相矛盾。我们采用荟萃分析方法探讨了盐摄入量与HF风险之间的剂量反应关系，研究方案已在国际前瞻性系统评价注册中心（PROSPERO）注册（ID：CRD 42020163680）。使用MEDLINE和EMBASE（从1950年1月1日到2019年9月30日），我们检索了与盐摄入量相关的HF风险的队列研究。研究必须使用24小时尿钠排泄（UNa）评估盐摄入量，方法是采集24小时尿液样本或根据现场尿液样本进行经验证的估计，并显示基线时受试者人数和按UNa分类的受试者HF事件的数据。1 g/天UNa相当于2.5 g/天的盐摄入量[4]。使用饮食评估（例如，食物频率问卷或24小时饮食回忆）评估盐摄入量的研究被排除在外，因为与实际摄入量相比，自我报告的盐摄入量被严重低估[5]。由于这项研究的重点是HF的一级预防，我们也排除了针对以下目标的研究：
There is a growing epidemic of heart failure (HF) worldwide. Hypertension and coronary heart disease (CHD) are major contributors to HF [1]. Increased salt intake is associated with a rise in blood pressure [2], and the risk of CHD-related mortality is well known [3]. The risk of HF is believed to be reduced with restricted salt intake. However, some data contradict this belief. We explored the doseresponse relationship between salt intake and HF risk using a meta-analytic approach.The study protocol was registered in the international prospective register of systematic reviews (PROSPERO)(ID: CRD42020163680). Using MEDLINE and EMBASE (from 1950 Jan. 1 to 2019 Sep. 30), we searched for cohort studies of HF risk related to salt intake. Studies had to assess salt intake using 24-h urine Na excretion (UNa) by collection of 24-h urine specimens or validated estimation from spot urine samples and show data on the number of participants at baseline and HF events for participants classified by UNa. A 1 g/day UNa corresponds to 2.5 g/day of salt intake [4]. Studies evaluating salt intake using dietary assessments (eg, food frequency questionnaire or 24-h dietary recall) were excluded because self-reported salt intake has been critically underestimated compared with actual intake [5]. Since this research focuses on primary prevention of HF, we also excluded studies targeting