Bacterial membrane vesicles with multiple lipid bilayers: vesicles harboring organelle-like structures
Bacterial membrane vesicles with multiple lipid bilayers: vesicles harboring organelle-like structures
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具有多个脂质双层的细菌膜囊泡：含有细胞器样结构的囊泡
DOI：
10.1093/bbb/zbac066
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Yosuke Tashiro
中科院分区：
文献类型：
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作者：
西村宜之;土屋渉;平山隆志;山崎俊正;Noriyuki Nishimura;Yosuke Tashiro
细菌产生外膜囊泡（OMV），其是主要由脂多糖、磷脂和外膜蛋白组成的球形纳米颗粒。OMV在应激反应、微生物通讯和细菌-宿主相互作用中发挥着重要的生物学作用。此外，它们在生物技术应用中具有巨大的潜力，因为它们在分子转运中具有多功能，同时保护内源性物质。虽然OMV被认为是脂质单层囊泡几十年来，最近的研究表明，膜囊泡（MV）与多个脂质双层，包括外-内膜囊泡，多层囊泡，和多泡囊泡，也产生革兰氏阴性菌。一些内部囊泡含有细胞质成分，如DNA，因此在MV中起细胞器样结构的作用。本文综述了近年来关于复杂结构MV的生物成因和特性的研究进展。
Bacteria produce outer membrane vesicles (OMVs), which are spherical nanoparticles that are mainly composed of lipopolysaccharides, phospholipids, and outer membrane proteins. OMVs play critical biological roles in stress responses, microbial communication, and bacteria–host interactions. Additionally, they hold great potential for biotechnological applications because of their versatile function in molecular transport while protecting the endogenous substances. While OMVs have been considered lipid monolamellar vesicles for several decades, recent studies have shown that membrane vesicles (MVs) with multiple lipid bilayers, including outer–inner membrane vesicles, multilamellar vesicles, and multivesicular vesicles, are also produced by Gram-negative bacteria. Some internal vesicles contain cytoplasmic components such as DNA and thus function as organelle-like structures within MVs. This review provides recent findings regarding the biogenesis and properties of MVs with complex structures.