Epidemiology of Oral HPV Infection and HPV-Associated Head and Neck Cancer
Epidemiology of Oral HPV Infection and HPV-Associated Head and Neck Cancer
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DOI：
10.1007/978-81-322-2413-6_2
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发表时间：
2015-01-01
期刊：
影响因子：
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通讯作者：
Sturgis, Erich M.
中科院分区：
文献类型：
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作者：
Dahlstrom, Kristina R.;Sturgis, Erich M.
烟草和酒精暴露是头颈部恶性肿瘤的传统危险因素，约占全球所有病例的四分之三，占美国病例的一半[1]。感染人乳头瘤病毒(HPV)，特别是16型，也被确定为另一个重要的危险因素[2-5]。绝大多数HPV相关性头颈癌(HPV-HNSCCs)发生在口咽部[2，6]。人乳头瘤病毒阳性的口咽癌(OPC)是一种病因学上越来越不同的头颈部癌症，具有不同于HPV阴性的独特的流行病学、临床和分子特征。
Tobacco and alcohol exposure are the traditional risk factors for malignancies of the head and neck, and account for approximately three-quarters of all cases worldwide and half of the cases in the USA [1]. Infection with human papillomavirus (HPV), particularly type 16, has also been established as yet another important risk factor [2–5]. The overwhelming majority of HPV-associated head and neck cancers (HPV-HNSCCs) arise from the oropharynx [2, 6]. HPV-positive oropharyngeal cancer (OPC) represents a growing aetiologically distinct subset of head and neck cancers, with unique epidemiological, clinical and molecular characteristics that differ from those of HPV-negative cancers.