Molecular genetics and molecular biology of dyslexia
Molecular genetics and molecular biology of dyslexia
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DOI：
10.1002/wcs.138
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发表时间：
2011-07-01
影响因子：
3.9
通讯作者：
Kere, Juha
中科院分区：
文献类型：
--
作者：
Kere, Juha
早在19世纪后期，发展性阅读障碍就被认为是学习障碍中的一个独特实体，其部分遗传性质已被家庭和双胞胎研究牢固地确立。遗传作图和分子克隆方法的应用已经揭示了导致遗传风险的特定基因，但这些已知的基因还不足以解释所有的遗传风险。更重要的是，第一批基因，其中一些是通过对罕见家族的研究发现的，表明了对阅读障碍的发展具有重要作用的特定神经发育过程，包括DYX1C1、DCDC2和KIAA0319基因的神经元迁移控制，以及ROBO1基因提示的轴突和树突引导作用。我预计，未来几年的研究将在阅读障碍的分子生物学中产生具有基本作用的分子网络，并可能有助于解决共病疾病之间的关系。2011 John Wiley & Sons, Ltd。电子学报2011年2 441-448 DOI: 10.1002/wcs.138
Developmental dyslexia has been recognized as a distinct entity among learning disabilities as early as the late 1800s and its partially genetic nature has been firmly established by family and twin studies. The application of genetic mapping and molecular cloning methods has revealed specific genes that contribute to the genetic risk, but those known now do not yet suffice for explaining all of it. More importantly, the first genes, some of them found by the study of rare families, have indicated specific neurodevelopmental processes important for the development of dyslexia, including control of neuronal migration for the DYX1C1, DCDC2, and KIAA0319 genes, and a role of axonal and dendritic guidance suggested by the ROBO1 gene. I anticipate that forthcoming research within only a few years will yield molecular networks with fundamental roles in the molecular biology of dyslexia, and may aid in resolving relationships between comorbid disorders.. 2011 John Wiley & Sons, Ltd. WIREs Cogn Sci 2011 2 441-448 DOI: 10.1002/wcs.138