Migraine and tumour necrosis factor gene polymorphism
Migraine and tumour necrosis factor gene polymorphism
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DOI：
10.1007/s00415-009-0961-8
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发表时间：
2009-02-01
影响因子：
6
通讯作者：
Del Zompo, Maria
中科院分区：
文献类型：
--
作者：
Asuni, C.;Stochino, M. E.;Del Zompo, Maria
为了评估TNF基因多态性和无先兆偏头痛之间的关联的可能性，在撒丁岛样本中进行了一项病例对照研究。无先兆偏头痛是一种复杂的遗传性疾病，其中易感性和环境因素对其发展有贡献。一些研究表明，肿瘤坏死因子（TNF）（TNF-α和α-光毒素或TNF-A）可能参与偏头痛的病理生理学。TNF-α和TNF-A基因位于染色体6p21.3的人类白细胞抗原（HLA）III类区域。我们评估了299例无先兆偏头痛（I.H.S.）患者。标准2004）和278例无偏头痛对照。采用NcoI限制性片段长度多态性分析方法检测TNF-α基因G308 A和TNF-β基因G252 A多态性，发现等位基因（p = 0.018; OR = 1.46 95% CI：1.066 ~ 2.023）和基因型频率（趋势卡方= 5.46，df = 1，p = 0.019）。TNF-alpha多态性的等位基因和基因型频率在两组之间没有显著差异，这些数据表明，TNFB 2等位基因的受试者患无先兆偏头痛的风险较低，和/或TNF-beta基因的多态性与HLA区域的其他偏头痛相关基因连锁不平衡。
To assess the possibility of an association between TNF gene polymorphisms and migraine without aura, a case-control study was performed in a Sardinian sample.Migraine without aura is a complex genetic disease in which susceptibility and environmental factors contribute towards its development. Several studies suggest that tumour necrosis factors (TNF) (TNF-alpha and lymphotoxin-alpha or TNF-A) may be involved in the pathophysiology of migraine. The TNF-alpha and TNF-A genes are located on chromosome 6p21.3 in the human leukocyte antigene (HLA) class III region. We evaluated 299 patients affected by migraine without aura (I.H.S. criteria 2004) and 278 migraine-free controls. The polymorphisms G308A of the TNF- alpha gene, and G252A of TNF-beta gene were determined by NcoI restriction fragment length polymorphism analysis.We found a statistically significant difference in allele (p = 0.018; OR = 1.46 95 % CI: 1.066 to 2.023) and genotype (trend chi 2 = 5.46, df = 1, p = 0.019) frequencies of TNF-beta gene, between cases and controls. Allele and genotype frequencies of TNF-alpha polymorphism did not differ significantly between the two groups.These data suggest that subjects with the TNFB2 allele have a low risk of developing migraine without aura and/or that the polymorphism of the TNF-beta gene is in linkage disequilibrium with other migraine responsible genes in the HLA region.