Effects of aniracetam on impaired sleep patterns in stroke‐prone spontaneously hypertensive rats
Effects of aniracetam on impaired sleep patterns in stroke‐prone spontaneously hypertensive rats
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DOI：
10.1046/j.1440-1819.2000.00693.x
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发表时间：
2000-06
影响因子：
11.9
通讯作者：
M. Kimura;Shukan Okano;S. Inoué
中科院分区：
文献类型：
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作者：
M. Kimura;Shukan Okano;S. Inoué
本研究的目的是确定认知增强剂阿尼拉西坦对卒中易感型自发性高血压大鼠(SHRSP)睡眠障碍的模式和对睡眠的影响。与正常血压对照组大鼠相比，SHRSP大鼠表现出以昼夜快速眼动(REM)睡眠抑制和夜间非REM睡眠过多为特征的睡眠损害模式。口服阿尼拉西坦30 mg/(kg·d)，连续给药5天后，可增加小鼠在光照期的REM睡眠。因此，SHRSP中受抑制的REM睡眠可通过重复使用阿尼拉西坦恢复。阿尼拉西坦可能有助于改善与血管性痴呆相关的REM睡眠障碍。
The aim of the present study was to determine the pattern of sleep disturbances and the effects on sleep of aniracetam, a cognitive enhancer, in stroke‐prone spontaneously hypertensive rats (SHRSP). Compared with normotensive control rats, SHRSP exhibited an impaired sleep pattern characterized by suppressed diurnal rapid eye movement (REM) sleep and excessive nocturnal non‐REM sleep. At a dose of 30 mg/kg per day p.o., aniracetam increased REM sleep in the light period after administration for 5 consecutive days. Consequently, suppressed REM sleep in SHRSP was restored by repeated treatment with aniracetam. Aniracetam could be useful in improving REM sleep impairment associated with vascular dementia.