Association of Cerebral Microbleeds with Cognitive Decline: A Longitudinal Study
Association of Cerebral Microbleeds with Cognitive Decline: A Longitudinal Study
复制标题
脑微出血与认知能力下降的关联：一项纵向研究
DOI：
10.3233/jad-191257
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发表时间：
2020-01-01
影响因子：
4
通讯作者：
Yu, Jin-Tai
中科院分区：
文献类型：
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作者：
Li, Lin;Wu, Dan-Hong;Yu, Jin-Tai
背景资料：脑微出血（CMB）在认知功能障碍中的作用仍然存在争议。Objective：To investigate the possible links between the presence，progression，number，and location of CMB and cognition.Methods：我们评估了792例阿尔茨海默病神经影像学倡议的受试者，他们接受了大脑3特斯拉MRI扫描和认知测试。采用线性混合效应模型（Linear Mixed Effect Models，LME）探讨了CMB与认知变化的关系。结果：CMB的存在和数量与记忆有关（β =-0.03，p = 0.015; β =-0.01，p = 0.003），执行功能（β =-0.04，p = 0.010; β =-0.01，p = 0.014）和整体认知功能（β =-0.06，p = 0.025; β =-0.03，p < 0.001）。CMB的进展与执行功能（β =-0.05，p = 0.025）和整体认知功能（β =-0.12，p = 0.015）呈显著负相关。与认知绩效的关系（记忆、执行功能和整体认知功能）主要由脑叶CMB驱动（分别为β =-0.03，p = 0.041; β =-0.04，p = 0.010; β =-0.07，p = 0.029），尤其是位于颞叶的（分别为β =-0.08，p = 0.027; β =-0.13，p = 0.001; β =-0.26，p < 0.001）。结论：脑白质高信号的存在、发展、数量和部位，尤其是颞叶脑白质高信号，与认知功能减退有关。这些发现表明CMB在认知障碍中起作用。
Background: The role of cerebral microbleeds (CMBs) in cognitive impairment remains controversial.Objective: To investigate the possible links between the presence, progression, number, and location of CMBs and cognition.Methods: We assessed 792 subjects from the Alzheimer's Disease Neuroimaging Initiative who underwent both brain 3 Tesla MRI scans and cognitive testing. The association between CMBs and cognitive change was explored using linear mixed-effects models (LME).Results: Presence and number of CMBs were associated with memory (beta = -0.03, p = 0.015; beta = -0.01, p = 0.003), executive function (beta = -0.04, p = 0.010; beta = -0.01, p = 0.014), and global cognitive function (beta = -0.06, p = 0.025; beta = -0.03, p < 0.001). Progression of CMBs showed significant negative associations with executive function (beta = -0.05, p = 0.025) and global cognitive function (beta = -0.12, p = 0.015). The relations with cognitive performance (memory, executive function and global cognitive function) were mainly driven by lobar CMBs (beta = -0.03, p = 0.041; beta = -0.04, p = 0.010; beta = -0.07, p = 0.029, respectively), especially those located in temporal lobe (beta = -0.08, p = 0.027; beta = -0.13, p = 0.001; beta = -0.26, p < 0.001, respectively). Furthermore, white matter hyperintensities may mediate the association between CMBs and cognition.Conclusion: The presence, progression, number, and location of CMBs, especially those located in temporal lobe, are associated with cognitive decline. These findings suggest CMBs play a role in cognitive impairment.