Gait Speed and Grip Strength Reflect Cognitive Impairment and Are Modestly Related to Incident Cognitive Decline in Memory Clinic Patients With Subjective Cognitive Decline and Mild Cognitive Impairment: Findings From the 4C Study
Gait Speed and Grip Strength Reflect Cognitive Impairment and Are Modestly Related to Incident Cognitive Decline in Memory Clinic Patients With Subjective Cognitive Decline and Mild Cognitive Impairment: Findings From the 4C Study
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DOI：
10.1093/gerona/glx003
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发表时间：
2017-06-01
影响因子：
5.1
通讯作者：
van der Flier, Wiesje M.
中科院分区：
文献类型：
--
作者：
Hooghiemstra, Astrid M.;Ramakers, Inez H. G. B.;van der Flier, Wiesje M.
背景资料：在普通人群中进行的前瞻性研究表明，缓慢的步态速度与认知能力下降和痴呆的临床进展有关。然而，记忆诊所人群的纵向研究大多缺乏。我们的目的是研究步态速度和握力和认知功能之间的关联，在基线和随着时间的推移，在记忆诊所患者的主观认知下降和轻度cognitiveimpairment.Methods：我们包括309例患者（年龄70 +/- 9岁，108 [35%]女性，简易精神状态检查27 +/- 3分）。基线步态速度评估超过15英尺，握力与液压手测力计。认知功能进行了评估，每年与一个全面的测试电池在3 years.Results：性别和性别调整的线性混合模型显示，较慢的步态速度与较差的基线注意力，记忆力，信息处理速度，和语言流畅性。纵向上，步态速度与信息处理速度和执行功能的下降有关。较弱的握力与较差的基线信息处理速度和执行功能有关，但没有纵向关联。考克斯比例风险模型显示，没有显着的协会与临床progress.Conclusions：我们的研究结果表明，标志物的身体表现与当前的认知状态和适度相关的认知能力下降，但似乎没有作为一个事件的临床进展的早期标志物有用。
Background: Prospective studies in the general population show that slow gait speed is associated with cognitive decline and clinical progression to dementia. However, longitudinal studies in memory clinic populations are mostly lacking. We aimed to study the association between gait speed and grip strength and cognitive functioning at baseline and cognitive decline over time in memory clinic patients with subjective cognitive decline and mild cognitive impairment.Methods: We included 309 patients (age 70 +/- 9 years, 108 [35%] women, Mini-Mental State Examination 27 +/- 3 points). Baseline gait speed was assessed over 15 feet, grip strength with a hydraulic hand dynamometer. Cognitive functioning was assessed annually with a comprehensive test battery during 3 years.Results: Age-and gender-adjusted linear mixed models showed that slower gait speed was related to worse baseline attention, memory, information processing speed, and verbal fluency. Longitudinally, gait speed was related to decline in information processing speed and executive functioning. Weaker grip strength was related to worse baseline information processing speed and executive functioning but there were no longitudinal associations. Cox proportional hazards models revealed no significant associations with clinical progression.Conclusions: Our findings suggest that markers of physical performance are related to current cognitive status and modestly related to cognitive decline but are seemingly not useful as an early marker of incident clinical progression.