Looming Signals Reveal Synergistic Principles of Multisensory Integration
Looming Signals Reveal Synergistic Principles of Multisensory Integration
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DOI：
10.1523/jneurosci.5517-11.2012
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发表时间：
2012-01-25
影响因子：
5.3
通讯作者：
Murray, Micah M.
中科院分区：
文献类型：
--
作者：
Cappe, Celine;Thelen, Antonia;Murray, Micah M.
多感官互动是大脑组织的基本特征。通过独立地改变刺激位置、时间和功效，已经建立了支配多感觉处理的原则。当刺激在它们的感知距离上动态变化时（如当逼近/后退时），确定这些原理是否以及如何操作，提供了对上述原理之间的协同作用的分析，并且还提供了用于将基本刺激与用于通信和运动规划的高阶信号之间的多感官相互作用联系起来的手段。人类参与者表示运动的隐现或后退与静态刺激，视觉，听觉，或多感官的组合，而160通道脑电图记录。进行多变量EEG分析和分布源估计。在电压波形、全局场功率和源估计的分析中，在早期刺激后延迟（类似于75 ms）观察到隐现信号之间的非线性相互作用。这些隐约可见的具体相互作用与反应时间促进呈正相关，提供了多感觉整合的神经和性能指标之间的直接联系。源估计的统计分析确定了隐约可见的特定的相互作用，在右屏状核/杏仁核内延伸到杏仁核，也在双侧楔叶内延伸到下枕叶和外侧枕叶皮质。多感官效应共同的所有条件下，无论感知的距离和一致性，其次（类似于115毫秒），表现为时间稳定的大脑网络之间的更快的过渡（与总和反应unisensory条件）。我们展示了早期潜伏期，多感官相互作用的现有原则之间的协同作用。这些发现改变了在神经和行为/感知水平上模拟多感官交互的方式。我们还提供了神经生理学支持的概念，隐现的信号在感知过程中得到优先处理。
Multisensory interactions are a fundamental feature of brain organization. Principles governing multisensory processing have been established by varying stimulus location, timing and efficacy independently. Determining whether and how such principles operate when stimuli vary dynamically in their perceived distance (as when looming/receding) provides an assay for synergy among the above principles and also means for linking multisensory interactions between rudimentary stimuli with higher-order signals used for communication and motor planning. Human participants indicated movement of looming or receding versus static stimuli that were visual, auditory, or multisensory combinations while 160-channel EEG was recorded. Multivariate EEG analyses and distributed source estimations were performed. Nonlinear interactions between looming signals were observed at early poststimulus latencies (similar to 75 ms) in analyses of voltage waveforms, global field power, and source estimations. These looming-specific interactions positively correlated with reaction time facilitation, providing direct links between neural and performance metrics of multisensory integration. Statistical analyses of source estimations identified looming-specific interactions within the right claustrum/insula extending inferiorly into the amygdala and also within the bilateral cuneus extending into the inferior and lateral occipital cortices. Multisensory effects common to all conditions, regardless of perceived distance and congruity, followed (similar to 115 ms) and manifested as faster transition between temporally stable brain networks (vs summed responses to unisensory conditions). We demonstrate the early-latency, synergistic interplay between existing principles of multisensory interactions. Such findings change the manner in which to model multisensory interactions at neural and behavioral/perceptual levels. We also provide neurophysiologic backing for the notion that looming signals receive preferential treatment during perception.