Ascorbate attenuates red light mediated vasodilation: Potential role of S-nitrosothiols
Ascorbate attenuates red light mediated vasodilation: Potential role of S-nitrosothiols
复制标题
DOI：
10.1016/j.redox.2018.09.008
复制
发表时间：
2019-01-01
期刊：
影响因子：
11.4
通讯作者：
Lohr, Nicole L.
中科院分区：
文献类型：
--
作者：
Keszler, Agnes;Lindemer, Brian;Lohr, Nicole L.
一氧化氮合酶 (NOS) 不依赖于一氧化氮 (NO) 的产生对于内皮细胞以及 NOS 功能障碍的疾病具有显着的治疗优势。红色和近红外区域的电磁辐射已被证明可以刺激不依赖于一氧化氮合酶（NOS）但依赖于一氧化氮（NO）的血管舒张，因此具有显着的治疗潜力。我们最近发现，红光通过释放内皮衍生物质，诱导预先收缩的小鼠面动脉发生急性血管舒张。在这项研究中，我们研究了血管舒张的机制，并得出结论：670 nm 光刺激内皮储备释放血管舒张剂，并且这种血管舒张剂具有 S-亚硝基硫醇 (RSNO) 的特征。这项研究表明，670 nm 照射可作为一种有针对性的非侵入性手段，从内皮储备中释放生物相关量的血管舒张剂。这提出了这样的可能性：这些储存可以在病理情况下通过药理方式建立，以提高红光治疗的功效。该策略可以克服外周血管病理中的 eNOS 功能障碍，从而改善血管健康。
There is significant therapeutic advantage of nitric oxide synthase (NOS) independent nitric oxide (NO) production in maladies where endothelium, and thereby NOS, is dysfunctional. Electromagnetic radiation in the red and near infrared region has been shown to stimulate NOS-independent but NO-dependent vasodilation, and thereby has significant therapeutic potential. We have recently shown that red light induces acute vasodilatation in the pre-constricted murine facial artery via the release of an endothelium derived substance. In this study we have investigated the mechanism of vasodilatation and conclude that 670 nm light stimulates vasodilator release from an endothelial store, and that this vasodilator has the characteristics of an S-nitrosothiol (RSNO). This study shows that 670 nm irradiation can be used as a targeted and non-invasive means to release biologically relevant amounts of vasodilator from endothelial stores. This raises the possibility that these stores can be pharmacologically built-up in pathological situations to improve the efficacy of red light treatment. This strategy may overcome eNOS dysfunction in peripheral vascular pathologies for the improvement of vascular health.