Body weight patterns from 20 to 49 years of age and subsequent risk for diabetes mellitus - The Johns Hopkins precursors study
Body weight patterns from 20 to 49 years of age and subsequent risk for diabetes mellitus - The Johns Hopkins precursors study
复制标题
DOI：
10.1001/archinte.159.9.957
复制
发表时间：
1999-05-10
影响因子：
--
通讯作者：
Klag, MJ
中科院分区：
文献类型：
--
作者：
Brancati, FL;Wang, NY;Klag, MJ
背景：众所周知，中年肥胖是发生 2 型糖尿病的危险因素。然而，体重和年轻时体重增加的重要性尚不明确。 目的 确定 20 至 49 岁的体重模式与随后患 2 型糖尿病的风险之间的关系。背景：一项针对前医学生的持续纵向研究。参与者：916 名 50 岁无糖尿病的白人男性。测量：在医学院测量体重和身高，然后通过邮寄问卷评估至 49 岁。主要结果：基于医生自我报告的 2 型糖尿病事件。结果：在 14 255 人年的随访期间，有 35 例 2 型糖尿病事件（每 1000 人中有 2.5 例）人年）。同时调整年龄、体力活动、母亲终生糖尿病史和吸烟情况后，25、35和45岁时的体重指数（BMI；计算方式为体重（公斤）除以身高（米）的平方）均与糖尿病风险密切相关（超重[BMI大于或等于25.0]与不超重的相对风险，>3.0；所有P值
Background: Obesity in middle age is a well-known risk factor for the development of type 2 diabetes mellitus. However, the importance of weight and weight gain at younger ages is less certain.Objective To determine the relationship of body weight patterns from 20 to 49 years of age with the subsequent risk for type 2 diabetes mellitus.Setting: An ongoing longitudinal study of former medical students. Participants: Nine hundred sixteen white men without diabetes at 50 years of age.Measurements: Weight and height measured in medical school, then assessed by mailed questionnaire to 49 years of age.Main Outcome: Incident type 2 diabetes mellitus based on physician self-report.Results: During 14 255 person-years of follow-up, there were 35 incident cases of type 2 diabetes mellitus (2.5 per 1000 person-years). After simultaneous adjustment for age, physical activity, lifetime maternal history of diabetes, and smoking, body mass indexes (BMIs; calculated as weight in kilograms divided by the square of height in meters) at 25, 35, and 45 years of age were all strongly associated with diabetes risk (relative risks for overweight [BMI greater than or equal to 25.0] vs not overweight, >3.0; all Ps