Salivary gland carcinoma: Independent prognostic factors for locoregional control, distant metastases, and overall survival: Results of the Dutch Head and Neck Oncology Cooperative Group
Salivary gland carcinoma: Independent prognostic factors for locoregional control, distant metastases, and overall survival: Results of the Dutch Head and Neck Oncology Cooperative Group
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DOI：
10.1002/hed.10400
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发表时间：
2004-08-01
影响因子：
2.9
通讯作者：
Roodenburg, JLN
中科院分区：
文献类型：
--
作者：
Terhaard, CHJ;Lubsen, H;Roodenburg, JLN
背景我们分析了在荷兰头颈肿瘤协作组中心诊断的恶性涎腺肿瘤患者的记录，以寻找局部区域控制、远处转移和总体生存的独立预后因素。在565例患者中，我们分析了一般结果，并寻找年龄，性别，延迟，临床和病理T和N分期，部位（腮腺332例，颌下76例，口腔129例，咽/喉28例），疼痛，面部无力，临床和病理皮肤受累，组织学类型（WHO 1972分类）、治疗、切除边缘、溢出、神经周围和血管侵犯、颈部淋巴结数量和淋巴结疾病。中位随访期为74个月;末次随访时存活的患者为99个月。10年后局部控制率、区域控制率、无远处转移率和总生存率分别为78%、87%、67%和50%。在多变量分析中，局部控制是由临床T分期、骨浸润、部位、切除边缘和治疗预测的。区域控制取决于N分期、面神经麻痹和治疗。单纯手术与手术加术后放疗相比，局部复发的相对风险为9.7，区域复发的相对风险为2.3。远处转移与T和N分期、性别、神经周围浸润、组织学类型和临床皮肤受累独立相关。总生存率取决于年龄、性别、T和pN分期、部位、皮肤和骨侵犯。研究发现局部区域控制、远处转移和总生存率的几个预后因素。术后放疗可改善局部区域控制。(C)2004 Wiley Periodicals，Inc.
Background. We analyzed the records of patients with malignant salivary gland tumors, as diagnosed in centers of the Dutch Head and Neck Oncology Cooperative Group, in search of independent prognostic factors for locoregional control, distant metastases, and overall survival.Methods. In 565 patients, we analyzed general results and looked for the potential prognostic variables of age, sex, delay, clinical and pathologic T and N stage, site (332 parotid, 76 submandibular, 129 oral cavity, 28 pharynx/larynx), pain, facial weakness, clinical and pathologic skin involvement, histologic type (WHO 1972 classification), treatment, resection margins, spill, perineural and vascular invasion, number of neck nodes, and extranodal disease. The median follow-up period was 74 months; it was 99 months for patients who were alive on the last follow-up.Results. The rates of local control, regional control, distant metastasis-free and overall survival after 10 years were, respectively, 78%, 87%, 67%, and 50%. In multivariable analysis, local control was predicted by clinical T stage, bone invasion, site, resection margin, and treatment. Regional control depended on N stage, facial nerve paralysis, and treatment. The relative risk with surgery alone, compared with surgery plus postoperative radiotherapy, was 9.7 for local recurrence and 2.3 for regional recurrence. Distant metastases were independently correlated with T and N stage, sex, perineural invasion, histologic type, and clinical skin involvement. Overall survival depended on age, sex, T and pN stage, site, skin and bone invasion.Conclusions. Several prognostic factors for locoregional control, distant metastases, and overall survival were found. Postoperative radiotherapy was found to improve locoregional control. (C) 2004 Wiley Periodicals, Inc.