RNA metabolism: strategies for regulation in the heat shock response.
RNA metabolism: strategies for regulation in the heat shock response.
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DOI：
10.1016/0168-9525(90)90183-7
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
H.Joseph Yost;Robert B. Petersen;Susan Linquist
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文献类型：
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作者：
H.Joseph Yost;Robert B. Petersen;Susan Linquist
P~‘NS~ZmNM，PML~Phul，PA 19104，美国L细胞对高于正常生长温度的温度的反应是通过诱导合成一小群进化上保守的多肽，即热休克蛋白(HSPs)。一些热休克蛋白需要帮助细胞在正常温度范围的上限el，d生长，另一些热休克蛋白帮助细胞抵御更极端温度的毒性影响。许多蛋白质也是在正常温度下产生的，或者有在正常温度下产生的近亲。热休克蛋白及其近亲参与了多种不同的细胞过程，包括DNA合成、蛋白质分泌、对类固醇激素的反应以及新合成蛋白质的组装(“陪伴”)。这些互动的多样性和复杂性才刚刚开始被揭开。然而，将热休克蛋白定义为一个组的是，当细胞暴露在更高的温度V4中时，它们的合成立即和非常戏剧性地增加。1为一般综述，参考文献12有关转录后调控的详细信息，参考文献3和4关于HSP功能的详细信息。在所研究的所有生物中，热休克导致热休克基因的立即转录激活，在许多生物中，热休克信息的优先翻译。热休克还会影响RNA新陈代谢的其他方面，包括RNA的加工和mRNA的降解。在Conte中：..在这些影响中，已经进化出额外的调控策略来促进HSP的合成。反过来，热休克蛋白的积累会影响RNA的代谢。热休克和热休克蛋白对RNA代谢的交互作用是本文的重点。我们之所以专注于果蝇的工作，是因为我们比其他任何生物都更了解这种有机体的转录后调控。然而，最近的信息表明，
OF P~'NS~ ZmNM, PmL~ PHUl, PA 19104, USA. l cells respond to temperatures above their normal growth temperatures by inducing the synthesis of a small group of evolutionarily conserved polypeptides known as the heat shock proteins (hsps). Some hsps are required to help cells grow at the upper el,, d of their normal temperature range, others help cells to withstand the toxic effects of more extreme temperatures. Many of the proteins are also produced at normal temperatures, or have close relatives that are produced at normal temperatures. The hsps and their relatives participate in an extraordinary variety of cellular processes, including DNA synthesis, protein secretion, the response to steroid hormones, and the assembly ('chaperoning') of newly synthesized proteins. The variety and complexity of these interactions are only beginning to be unraveled. What defines the hsps as a group, however, is the immediate and very dramatic increase in their synthesis when cells are exposed to higher temperaturesV4.(See Ref. 1 for a general review, Ref. 2 for details of post-transcriptional regulation and Refs 3 and 4 for details of hsp function.) In all organisms investigated, heat shock results in the immediate transcriptional activation of heat shock genes and, in many, the preferential translation of heat shock messages. Heat shock also affects other aspects of RNA metabolism, including RNA processing and mRNA degradation. Within the conte:.. t of these effects, additional regulatory strategies have evolved to promote hsp synthesis. In turn, the accumulation of hsps influences RNA metabolism. The interacting effects of heat shock and of hsps on RNA metabolism are the focus of this review. We have concentrated on the work in Drosophila because more is known about post-transcriptional regulation in this organism than in any other. Recent information suggests, however, that