Selective nociceptor activation in volunteers by infrared diode laser.
Selective nociceptor activation in volunteers by infrared diode laser.
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红外二极管激光在志愿者中的选择性伤害感受器。
DOI：
10.1186/1744-8069-7-18
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发表时间：
2011-03-22
期刊：
影响因子：
3.3
通讯作者：
Yeomans DC
中科院分区：
文献类型：
--
作者：
Tzabazis AZ;Klukinov M;Crottaz-Herbette S;Nemenov MI;Angst MS;Yeomans DC
两类主要的外周感觉神经元参与热痛敏感性：无髓鞘C纤维和薄髓鞘Aδ纤维。这两种纤维类型可能是不同临床疼痛状态和镇痛治疗效果差异的基础。C和Aδ热痛的差异测试方法在动物实验中被广泛使用，但这些方法并不适合人类志愿者和患者使用。因此，该项目旨在提供心理物理和电生理证据，以证明不同方案的红外二极管激光刺激是否可以直接激活皮肤深处的伤害性终端，从而不同地激活志愿者的α或C纤维热感受器。短脉冲（60 ms）、高强度激光脉冲（SP）诱发单模“刺痛感”，局部辣椒素不增强这种疼痛，而长脉冲、低功率激光脉冲（LP）诱发单模“灼痛感”，局部辣椒素增强这种疼痛。SP也产生了与Aδ介导一致的皮质诱发脑电图电位，其振幅与疼痛强度直接相关，但不受外用辣椒素的影响。LP还产生了明显的诱发电位模式，其振幅也与疼痛强度相关，局部辣椒素增强了疼痛强度，其潜伏期可以用来估计介导伤害性纤维的传导速度。心理物理和电生理数据与短高强度红外激光脉冲选择性产生Aδ介导的疼痛和长脉冲选择性产生C纤维介导的热痛的能力一致。因此，使用这些或类似的方案可能有助于开发和测试基于两种纤维类型（例如，TRPV1， TRPV2等）激活的差异分子机制的新疗法。此外，这些方案可能有助于确定不同临床疼痛类型的纤维调解，从而有助于治疗选择。
Two main classes of peripheral sensory neurons contribute to thermal pain sensitivity: the unmyelinated C fibers and thinly myelinated Aδ fibers. These two fiber types may differentially underlie different clinical pain states and distinctions in the efficacy of analgesic treatments. Methods of differentially testing C and Aδ thermal pain are widely used in animal experimentation, but these methods are not optimal for human volunteer and patient use. Thus, this project aimed to provide psychophysical and electrophysiological evidence that whether different protocols of infrared diode laser stimulation, which allows for direct activation of nociceptive terminals deep in the skin, could differentially activate Aδ or C fiber thermonociceptors in volunteers. Short (60 ms), high intensity laser pulses (SP) evoked monomodal "pricking" pain which was not enhanced by topical capsaicin, whereas longer, lower power pulses (LP) evoked monomodal "burning" pain which was enhanced by topical capsaicin. SP also produced cortical evoked EEG potentials consistent with Aδ mediation, the amplitude of which was directly correlated with pain intensity but was not affected by topical capsaicin. LP also produced a distinct evoked potential pattern the amplitude of which was also correlated with pain intensity, which was enhanced by topical capsaicin, and the latency of which could be used to estimate the conduction velocity of the mediating nociceptive fibers. Psychophysical and electrophysiological data were consistent with the ability of short high intensity infrared laser pulses to selectively produce Aδ mediated pain and of longer pulses to selectively produce C fiber mediated thermal pain. Thus, the use of these or similar protocols may be useful in developing and testing novel therapeutics based on the differential molecular mechanisms underlying activation of the two fiber types (e.g., TRPV1, TRPV2, etc). In addition, these protocol may be useful in determining the fiber mediation of different clinical pain types which may, in turn be useful in treatment choice.
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影响因子：
2.5
作者：
Tran, TD;Lam, K;Kakigi, R
通讯作者：
Kakigi, R
DOI：
10.1016/0013-4694(88)90020-x
发表时间：
1988-11-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
TREEDE, RD;KIEF, S;BROMM, B
通讯作者：
BROMM, B
影响因子：
2.5
作者：
BAUMANN, TK;SIMONE, DA;LAMOTTE, RH
通讯作者：
LAMOTTE, RH
影响因子：
4.6
作者：
MEYER, RA;WALKER, RE;MOUNTCASTLE, VB
通讯作者：
MOUNTCASTLE, VB
影响因子：
7.4
作者：
Veldhuijzen, Dieuwke S.;Nemenov, Michael I.;Greenspan, Joel D.
通讯作者：
Greenspan, Joel D.