Red Cell Distribution Width Is Associated with All-Cause and Cardiovascular Mortality in Patients with Diabetes.
Red Cell Distribution Width Is Associated with All-Cause and Cardiovascular Mortality in Patients with Diabetes.
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DOI：
10.1155/2017/5843702
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发表时间：
2017
影响因子：
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通讯作者：
Abi Khalil C
中科院分区：
文献类型：
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作者：
Al-Kindi SG;Refaat M;Jayyousi A;Asaad N;Al Suwaidi J;Abi Khalil C
红细胞分布宽度（RDW）已成为心血管疾病患者的预后指标。我们调查了国家健康和营养检查调查中糖尿病患者的死亡率，与基线RDW的关系。RDW分为4个四分位数（Q1：≤ 12.4%，Q2：12.5%-12.9%，Q3：13.0%-13.7%，Q4：>13.7%）。 共纳入3，061例患者：平均年龄61 ± 14岁，50%为男性，39%为白色。平均RDW为13.2% ± 1.4%。与RDW的第一四分位数（Q1）相比，Q4中的患者更可能是老年人、女性和非洲裔美国人，有卒中、心肌梗死和心力衰竭病史，并有慢性肾脏疾病。中位随访6年后，628例患者死亡（29%的心血管疾病）。与Q1相比，Q4患者的全因死亡率（HR 3.44 [2.74-4.32]，P <0.001）和心血管死亡率（HR 3.34 [2.16-5.17]，P <0.001）风险增加。在调整17个协变量后，Q4的RDW仍然与全因死亡率（HR 2.39 [1.30-4.38]，P = 0.005）和心血管死亡率（HR 1.99 [1.17-3.37]，P = 0.011）显著相关。 RDW是预测糖尿病患者全因死亡率和心血管死亡率的一个强有力的独立指标。
Red cell distribution width (RDW) has emerged as a prognostic marker in patients with cardiovascular diseases. We investigated mortality in patients with diabetes included in the National Health and Nutrition Examination Survey, in relation to baseline RDW. RDW was divided into 4 quartiles (Q1: ≤12.4%, Q2: 12.5%–12.9%, Q3: 13.0%–13.7%, and Q4: >13.7%). A total of 3,061 patients were included: mean age 61 ± 14 years, 50% male, 39% White. Mean RDW was 13.2% ± 1.4%. Compared with first quartile (Q1) of RDW, patients in Q4 were more likely to be older, female, and African-American, have had history of stroke, myocardial infarction, and heart failure, and have chronic kidney disease. After a median follow-up of 6 years, 628 patient died (29% of cardiovascular disease). Compared with Q1, patients in Q4 were at increased risk for all-cause mortality (HR 3.44 [2.74–4.32], P < .001) and cardiovascular mortality (HR 3.34 [2.16–5.17], P < .001). After adjusting for 17 covariates, RDW in Q4 remained significantly associated with all-cause mortality (HR 2.39 [1.30–4.38], P = 0.005) and cardiovascular mortality (HR 1.99 [1.17–3.37], P = 0.011). RDW is a powerful and an independent marker for prediction of all-cause mortality and cardiovascular mortality in patients with diabetes.