Modeling the role of negative symptoms in determining social functioning in individuals at clinical high risk of psychosis.
Modeling the role of negative symptoms in determining social functioning in individuals at clinical high risk of psychosis.
复制标题
模拟负面症状在确定精神病高风险下个体的社会功能中的作用。
DOI：
10.1016/j.schres.2015.10.036
复制
发表时间：
2015-12
影响因子：
4.5
通讯作者：
Vinogradov S
中科院分区：
文献类型：
--
作者：
Schlosser DA;Campellone TR;Biagianti B;Delucchi KL;Gard DE;Fulford D;Stuart BK;Fisher M;Loewy RL;Vinogradov S
A priority for improving outcome in individuals at clinical high risk (CHR) is enhancing our understanding of predictors of psychosis as well as psychosocial functioning. Social functioning, in particular, is a unique indicator of risk as well as an important outcome in itself. Negative symptoms are a significant determinant of social functioning in CHR individuals; yet, it is unclear which specific negative symptoms drive functional outcome and how these symptoms function relative to other predictors, such as neurocognition and mood/anxiety symptoms. In a sample of 85 CHR individuals, we examined whether a two-factor negative symptom structure that is found in schizophrenia (experiential vs expressive symptoms) would be replicated in a CHR sample; and tested the degree to which specific negative symptoms predict social functioning, relative to neurocognition and mood/anxiety symptoms, which are known to predict functioning. The two-factor negative symptom solution was replicated in this CHR sample. Negative symptom severity was found to be uniquely predictive of social functioning, above and beyond depression/anxiety and neurocognition. Experiential symptoms were more strongly associated with social functioning, relative to expression symptoms. In addition, experiential symptoms mediated the relationship between expressive negative symptoms and social functioning. These results suggest that experiences of motivational impairment are more important in determining social functioning, relative to affective flattening and alogia, in CHR individuals, thereby informing the development of more precise therapeutic targets. Developing novel interventions that stimulate goal-directed behavior and reinforce rewarding experiences in social contexts are recommended.
