9-O-acetyl sialic acid levels identify committed progenitors of plasmacytoid dendritic cells.
9-O-acetyl sialic acid levels identify committed progenitors of plasmacytoid dendritic cells.
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9-O-乙酰唾液酸水平可识别浆细胞样树突状细胞的定型祖细胞。
DOI：
10.1093/glycob/cwz062
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发表时间：
2019
期刊：
影响因子：
4.3
通讯作者：
Pillai,Shiv
中科院分区：
文献类型：
--
作者：
Netravali,IlkaA;Cariappa,Annaiah;Yates,Kathleen;Haining,WNicholas;Bertocchi,Alice;Allard-Chamard,Hugues;Rosenberg,Ian;Pillai,Shiv
浆细胞样树突状细胞（pDC）的起源长期以来一直存在争议，并且专门致力于该谱系的祖细胞尚未被描述。我们在这里表明，造血祖细胞的命运部分是由其表面的9-O-乙酰唾液酸水平。Pro-pDC被鉴定为谱系阴性的9- 0-乙酰基唾液酸低祖细胞，其缺乏骨髓和淋巴潜能，但分化成pre-pDC。后一种细胞也是谱系阴性的9- 0-乙酰基唾液酸低细胞，但仅定向于pDC谱系。9-O-乙酰基唾液酸的水平提供了一种独特的方式来定义祖细胞，从而促进造血分化的研究。
The origins of plasmacytoid dendritic cells (pDCs) have long been controversial and progenitors exclusively committed to this lineage have not been described. We show here that the fate of hematopoietic progenitors is determined in part by their surface levels of 9-O-acetyl sialic acid. Pro-pDCs were identified as lineage negative 9-O-acetyl sialic acid low progenitors that lack myeloid and lymphoid potential but differentiate into pre-pDCs. The latter cells are also lineage negative, 9-O-acetyl sialic acid low cells but are exclusively committed to the pDC lineage. Levels of 9-O-acetyl sialic acid provide a distinct way to define progenitors and thus facilitate the study of hematopoietic differentiation.