Testosterone has rewarding affective properties in male rats: implications for the biological basis of sexual motivation.
Testosterone has rewarding affective properties in male rats: implications for the biological basis of sexual motivation.
复制标题
睾酮对雄性大鼠具有有益的情感特性：对性动机的生物学基础的影响。
DOI：
10.1037//0735-7044.108.2.424
复制
发表时间：
1994
影响因子：
1.9
通讯作者：
Hines,M
中科院分区：
文献类型：
--
作者：
Alexander,GM;Packard,MG;Hines,M
来自哺乳动物物种（包括人类）的证据表明，睾酮（TST）增强了性行为的动机方面，尽管TST发挥这种作用的机制尚不清楚。血浆TST增加具有奖励情感特性的假设进行了检查。通过全身给予最近开发的睾酮-羟丙基-β-环糊精包合物（模拟激素的脉冲释放），在完整雄性大鼠中诱导血浆TST急性升高。在条件性位置偏好范例中，大鼠表现出对先前与TST给药（800 μg/kg和1，200 μg/kg）配对的环境的偏好，而不是与盐水给药配对的环境，表明TST具有奖励情感特性。研究结果表明，TST可能通过促进环境刺激和性活动之间的习得性关联的获得或表达来增强哺乳动物性行为的动机方面。（PsycINFO数据库记录（c）2016阿帕，保留所有权利）
Evidence from mammalian species, including humans, suggests that testosterone (TST) enhances motivational aspects of sexual behavior, although the mechanism by which TST exerts this effect is unknown. The hypothesis that increases in plasma TST have rewarding affective properties was examined. Acute elevations of plasma TST were induced in intact male rats by systemic administration of a recently developed testosterone-hydroxypropyl-β-cyclodextrin inclusion complex that mimics pulsatile release of the hormone. In a conditioned-place-preference paradigm, rats displayed a preference for an environment previously paired with TST administration (800 μg/kg and 1,200 μg/kg) as opposed to an environment paired with saline administration, indicating that TST has rewarding affective properties. The findings suggest that TST may enhance motivational aspects of mammalian sexual behavior by facilitating acquisition or expression of learned associations between environmental stimuli and sexual activity.(PsycINFO Database Record (c) 2016 APA, all rights reserved)