Models of dengue virus infection.
Models of dengue virus infection.
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DOI：
10.1016/j.ddmod.2006.03.014
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发表时间：
2006-01-01
期刊：
影响因子：
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通讯作者：
Rico-Hesse, Rebeca
中科院分区：
文献类型：
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作者：
Bente, Dennis A;Rico-Hesse, Rebeca
随着这种蚊媒病毒的传播急剧增加，对登革热疾病模型的需求达到了顶峰。人们对导致登革热及其更严重形式登革出血热的机制知之甚少;这是因为只有人类才会表现出疾病的迹象。在过去的5年中，研究已经更好地确定了感染的初始靶细胞，这导致了原代人类细胞培养中感染模型的发展。含有这些靶细胞的鼠-人嵌合体也导致了动物模型开发的进展。这些进展应该很快结束在测试抗病毒药物和疫苗制剂方面的僵局，这些药物和疫苗制剂必须在不完整或不相关的模型中进行。
The need for models of dengue disease has reached a pinnacle as the transmission of this mosquito-borne virus has increased dramatically. Little is known about the mechanisms that lead to dengue fever and its more severe form, dengue hemorrhagic fever; this is owing to the fact that only humans show signs of disease. In the past 5 years, research has better identified the initial target cells of infection, and this has led to the development of models of infection in primary human cell cultures. Mouse-human chimeras, containing these target cells, have also led to progress in developing animal models. These advances should soon end the stalemate in testing antivirals and vaccine preparations that had necessarily been done in incomplete or irrelevant models.