Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis.
Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis.
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DOI：
10.1038/srep15179
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发表时间：
2015-10-14
影响因子：
4.6
通讯作者：
Liu Y
中科院分区：
文献类型：
--
作者：
Shang B;Liu Y;Jiang SJ;Liu Y
FoxP 3+调节性T细胞（TCRs）在癌症中的预后价值仍然存在争议。我们进行了一项荟萃分析，以评估FoxP 3 + Treg在不同类型癌症中的预后作用，并研究与这种作用变化相关的因素。检索PubMed、Embase、科克伦CENTRAL和Scopus，以确定合格的研究。我们总共分析了76篇文章，包括17种癌症，包括15，512例癌症病例。包括所有类型的癌症的总体汇总分析表明FoxP 3 + THBG对总生存期（OS）有显著的负性影响（OR 1.46，P < 0.001），但预后影响因肿瘤部位而异。在大多数研究的实体瘤中，FoxP 3 + TcB高浸润与较短的OS显著相关，包括宫颈癌、肾癌、黑色素瘤和乳腺癌等;而在结直肠癌、头颈癌和食管癌中，FoxP 3 + TcB与改善的生存率相关。分层分析提示，FoxP 3 + TcR在某些类型肿瘤中的预后价值与肿瘤分期及分子亚型有关。总之，我们的荟萃分析表明，FoxP 3 + T细胞的预后作用是高度影响肿瘤部位，也与分子亚型和肿瘤分期。
The prognostic value of FoxP3+ regulatory T cells (Tregs) in cancer remains controversial. We did a meta-analysis to assess the prognostic effect of FoxP3+ Treg across different types of cancer and to investigate factors associated with variations in this effect. PubMed, Embase, Cochrane CENTRAL, and Scopus were searched to identify eligible studies. In total, we analyzed 76 articles encompassing 17 types of cancer, and including 15,512 cancer cases. The overall pooled analysis including all types of cancer suggested FoxP3+Tregs had a significant negative effect on overall survival (OS) (OR 1.46, P < 0.001), but the prognostic effect varied greatly according to tumor site. High FoxP3+ Tregs infiltration was significantly associated with shorter OS in the majority of solid tumors studied, including cervical, renal, melanomas, and breast cancers, et al; whereas, FoxP3+ Tregs were associated with improved survival in colorectal, head and neck, and oesophageal cancers. The stratified analysis suggested the molecular subtype and tumor stage significantly influenced the prognostic value of FoxP3+ Tregs in certain types of cancer. In conclusion, our meta-analysis suggests that the prognostic role of FoxP3+ Tregs was highly influenced by tumor site, and was also correlated with the molecular subtype and tumor stage.