Fourier transform Raman microscopic study of drug distribution in a transdermal drug delivery device
Fourier transform Raman microscopic study of drug distribution in a transdermal drug delivery device
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DOI：
10.1016/0924-2031(95)00066-6
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发表时间：
1996-05-01
影响因子：
2.5
通讯作者：
Williams, AC
中科院分区：
文献类型：
--
作者：
Armstrong, GL;Edwards, HGM;Williams, AC
利用傅里叶变换拉曼显微镜的测绘设备构建了雌激素在经皮给药装置(激素替代疗法贴片)中的分布轮廓。在包含用于表征的结晶材料的贴片的区域上进行标绘，使用显微镜设备获得的光谱与纯雌二醇和从乙醇重结晶的纯雌二醇的光谱进行比较。光谱清楚地显示固体包裹体是雌二醇，晶体附近的雌二醇浓度增加；由此得出结论，药物在制造过程中的某个阶段已经在贴片中结晶。结果表明，测绘工具在表征和确定复杂系统中组件的同质性方面具有很高的价值。
The mapping facility of a Fourier transform Raman microscope was used to construct a profile of oestradiol distribution in a transdermal drug delivery device (Hormone Replacement Therapy patch). Mapping was performed across a region of the patch which contained crystallised material for characterisation, The spectra acquired using the microscope facility were compared with those obtained of pure oestradiol and of pure oestradiol recrystallised from ethanol. The spectra clearly show the solid inclusions to be oestradiol, and that there is an increase in oestradiol concentration in the neighbourhood of the crystal; it was concluded that the drug had crystallised in the patch at some stage during the manufacturing process. The results demonstrate the value of the mapping facility in characterising and determining the homogeneity of components in a complex system.