Mesolimbic Functional Magnetic Resonance Imaging Activations during Reward Anticipation Correlate with Reward-Related Ventral Striatal Dopamine Release
Mesolimbic Functional Magnetic Resonance Imaging Activations during Reward Anticipation Correlate with Reward-Related Ventral Striatal Dopamine Release
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DOI：
10.1523/jneurosci.2058-08.2008
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发表时间：
2008-12-24
影响因子：
5.3
通讯作者：
Bauer, Andreas
中科院分区：
文献类型：
--
作者：
Schott, Bjoern H.;Minuzzi, Luciano;Bauer, Andreas
控制奖励动机行为的多巴胺能机制是一个深入研究的主题，但目前尚不清楚，在人类中，中边缘奖励回路的神经活动及其功能性神经成像相关物如何与多巴胺释放相关。为了解决这个问题，我们获得了功能性磁共振成像（fMRI）测量的奖励相关神经活动和[(11)C]raclopride正电子发射断层扫描测量的多巴胺释放，同时他们执行延迟的金钱激励任务。在整个队列中，多巴胺能神经传递的主要来源黑质/腹侧被盖区（SN/VTA）的神经活动与奖励相关[(11)C]raclopride位移作为腹侧纹状体（SN/VTA多巴胺神经元的主要靶点）多巴胺释放的指标之间存在正相关。腹侧纹状体/伏隔核本身的神经活动也与腹侧纹状体多巴胺释放相关。此外，与高奖励相关的多巴胺释放与杏仁核和海马体等边缘结构的激活增加有关。观察到奖励相关的中边缘fMRI激活与多巴胺释放的相关性，证明多巴胺能神经传递在人类中边缘奖励加工中起定量作用。此外，这里使用的神经化学和血流动力学成像方法为研究人类认知的分子机制开辟了新的视角。
The dopaminergic mechanisms that control reward-motivated behavior are the subject of intense study, but it is yet unclear how, in humans, neural activity in mesolimbic reward-circuitry and its functional neuroimaging correlates are related to dopamine release. To address this question, we obtained functional magnetic resonance imaging (fMRI) measures of reward-related neural activity and [(11)C]raclopride positron emission tomography measures of dopamine release in the same human participants, while they performed a delayed monetary incentive task. Across the cohort, a positive correlation emerged between neural activity of the substantia nigra/ventral tegmental area (SN/VTA), the main origin of dopaminergic neurotransmission, during reward anticipation and reward-related [(11)C]raclopride displacement as an index of dopamine release in the ventral striatum, major target of SN/VTA dopamine neurons. Neural activity in the ventral striatum/nucleus accumbens itself also correlated with ventral striatal dopamine release. Additionally, high-reward-related dopamine release was associated with increased activation of limbic structures, such as the amygdala and the hippocampus. The observed correlations of reward-related mesolimbic fMRI activation and dopamine release provide evidence that dopaminergic neurotransmission plays a quantitative role in human mesolimbic reward processing. Moreover, the combined neurochemical and hemodynamic imaging approach used here opens up new perspectives for the investigation of molecular mechanisms underlying human cognition.