Survival analysis and prognostic factors of the carcinoma of gallbladder.
Survival analysis and prognostic factors of the carcinoma of gallbladder.
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DOI：
10.1186/s12957-022-02857-y
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发表时间：
2022-12-20
影响因子：
3.2
通讯作者：
Kumar, Munish
中科院分区：
文献类型：
--
作者：
Feroz, Zainab;Gautam, Priyanka;Tiwari, Sonia;Shukla, Girish C.;Kumar, Munish
本研究旨在评估胆囊癌（GBC）患者的生存状况，并探讨改善和预防的预后因素。该研究由 176 名临床诊断为胆囊癌的患者组成；该研究于 2019 年至 2021 年间在印度 Prayagraj 的卡马拉尼赫鲁纪念癌症医院注册进行。采用Kaplan-Meier法分析存活率；采用log-rank检验分析生存率差异、预后因素；使用Cox回归方法估计死亡率结果的风险比。患者总体中位生存时间为5个月，1年、2年和3年生存率分别为24.4%、8.5%和4.5%。患有黄疸、肝脏浸润（4.2%）、胆结石（0.8%）和晚期肿瘤分级（1.4%）的患者的3年生存率为2.9%。老年GBC患者的生存率较低（3.8%），而居住在城市地区的患者的3年总生存率降至零。肿瘤分期（T3/T4）和远处转移期患者在3年内无一存活，而晚期淋巴结期患者仅有1.1%存活。接受手术和放射治疗后，3年生存率分别提高至19.5%和35%。多因素分析结果显示，城市地区（HR = 1.568，p = 0.040）、是否患有胆结石（1.571，p = 0.049）、N分期（HR = 1.468，p = 0.029）和M分期（HR = 2.289，p < 0.0001）是预后的独立危险因素，而是否手术（HR = 0.573，p = 0.030）是GBC预后的保护因素。 GBC在恒河带的总体生存率很差。患者地域、胆结石、N、M分期是GBC预后的危险因素，而手术与否是GBC预后的保护因素。
The present study aims to evaluate the survival status of patients with gallbladder cancer (GBC) and explore the prognostic factors for the improvement and preventions. The study consists of 176 patients with clinically diagnosed gallbladder cancer; the study was conducted between 2019 and 2021 registered at Kamala Nehru Memorial Cancer Hospital, Prayagraj, India. The survival rates were analyzed by the Kaplan-Meier method; survival rate difference was analyzed by log-rank test, prognosis factors; and hazard ratio for mortality outcomes was estimated using Cox regression method. The overall median survival time of patients was 5 months with the 1-year, 2-year, and 3-year survival rates of 24.4%, 8.5%, and 4.5%, respectively. The 3-year survival for patients with jaundice was 2.9%, liver infiltration (4.2%), gallstones (0.8%), and with advanced tumor grade (1.4%). Elderly GBC patients had lower survival rates (3.8%), while the 3-year overall survival for patients residing in urban areas dropped to zero. No patients in the tumor stage (T3/T4) and with distance metastasis stage survived in 3 years, while only 1.1% of patients with advanced nodal stage survived. On receiving surgery and radiation therapy, the 3-year survival rate increased to 19.5% and 35%, respectively. The results of multivariate analysis showed that urban region (HR = 1.568, p = 0.040), gallstone or not (1.571, p = 0.049), N stage (HR = 1.468, p = 0.029), and M stage (HR = 2.289, p < 0.0001) were independent risk factors for prognosis, while surgery or not (HR = 0.573, p = 0.030) was the protective factor for the prognosis of GBC. The overall survival of GBC in the Gangetic belt is poor. The geographical region of patients, gallstones, and N and M stage was the risk factors for prognosis, while surgery or not was the protective factor for the prognosis of GBC.
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基于贝叶斯网络的胆囊癌术后生存预后因素分析
影响因子：
4.6
作者：
Cai ZQ;Guo P;Si SB;Geng ZM;Chen C;Cong LL
通讯作者：
Cong LL
DOI：
10.1111/j.1440-1746.2005.03576.x
发表时间：
2005-02-01
影响因子：
4.1
作者：
Batra, Y;Pal, S;Tandon, RK
通讯作者：
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影响因子：
4.7
作者：
Soliman, Amr S.;Lo, An-Chi;Hamilton, Stanley R.
通讯作者：
Hamilton, Stanley R.
DOI：
10.1186/s12995-016-0128-3
发表时间：
2016
期刊：
Journal of occupational medicine and toxicology (London, England)
影响因子：
--
作者：
Singh Z;Chadha P
通讯作者：
Chadha P
影响因子：
9.8
作者：
Ryu, Seungho;Chang, Yoosoo;Shin, Hocheol
通讯作者：
Shin, Hocheol