Selective Co/Ti cooperatively catalyzed biaryl couplings of aryl halides with aryl metal reagents.
Selective Co/Ti cooperatively catalyzed biaryl couplings of aryl halides with aryl metal reagents.
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DOI：
10.1021/ol402599f
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发表时间：
2013-10
期刊：
影响因子：
5.2
通讯作者：
Jing Zeng;Kun Liu;Xinfang Duan
中科院分区：
文献类型：
--
作者：
Jing Zeng;Kun Liu;Xinfang Duan
各种芳基溴化物或氯化物，包括那些含有游离COOH、OH、CONHR和SO2NHR基团的化合物，与芳基镁或锂试剂在7.5mol%CoCl2/15mol%PBu3和亚化学计量比的Ti(OEt)4(对ARM的40mol%)存在下，在室温下以高的化学选择性和区域选择性高产率地合成。这一简单的反应代表了钴/钛协同催化的第一个例子，它在抑制不必要的同质偶联方面发挥了关键作用。
Various aryl bromides or chlorides, including those bearing a free COOH, OH, CONHR, and SO2NHR group, coupled with aryl magnesium or lithium reagents in the presence of 7.5 mol % CoCl2/15 mol % PBu3 and substoichiometric Ti(OEt)4 (40 mol % to ArM) at room temperature in high yields with high chemo- and regioslectivity. This simple reaction represents the first example of Co/Ti cooperative catalysis which plays a key role in suppressing undesired homocouplings.