Cerebral Blood Flow and Metabolism Measurement Using Positron Emission Tomography before and during Internal Carotid Artery Test Occlusions: Feasibility of Rapid Quantitative Measurement of CBF and OEF/CMRO2
Cerebral Blood Flow and Metabolism Measurement Using Positron Emission Tomography before and during Internal Carotid Artery Test Occlusions: Feasibility of Rapid Quantitative Measurement of CBF and OEF/CMRO2
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DOI：
10.1177/159101991201800304
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发表时间：
2012-09-01
影响因子：
1.7
通讯作者：
Tamiya, T.
中科院分区：
文献类型：
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作者：
Kawai, N.;Kawanishi, M.;Tamiya, T.
颈内动脉球囊试验闭塞(BTO)结合脑血流量(CBF)检测是预测永久性颈内动脉闭塞预后的敏感方法。然而，使用单光子发射断层扫描(SPECT)有时会出现假阴性结果。我们最近开发了一种快速正电子发射断层扫描(PET)方法，不仅可以测量脑血流量，还可以连续测量BTO前和BTO中的脑氧代谢。我们使用快速正电子发射计算机断层扫描技术测量了3例大型或巨大脑动脉瘤患者BTO术前和术中局部CBF和OEF/CMRO2的急性变化。虽然在BTO术中没有患者表现出缺血症状，但PET检查显示与BTO术前相比，所有患者的CBF都有轻微到中度的下降(9%类似于34%)。2例术中平均OEF较术前明显增加(分别为21%和43%)。这两个病例被认为是永久性颈内动脉闭塞不耐受的病例，在没有ICA牺牲的情况下接受治疗。在BTO术前和术中使用快速PET方法测量CBF和OEF/CMRO2是可行的，可用于准确评估ICA闭塞耐受性的预测。
Balloon test occlusion (BTO) of the internal carotid artery (ICA) combined with cerebral blood flow (CBF) study is a sensitive test for predicting the outcome of permanent ICA occlusion. However, false negative results sometimes occur using single photon emission tomography (SPECT). We have recently developed a rapid positron emission tomography (PET) protocol that measures not only the CBF but also the cerebral oxygen metabolism before and during BTO in succession. We measured acute changes in regional CBF and OEF/CMRO2 before and during BTO in three cases with large or giant cerebral aneurysms using the rapid PET protocol.Although no patients showed ischemic symptoms during BTO, PET studies exhibited mildly to moderately decreased CBF (9 similar to 34%) compared to the values obtained before BTO in all cases. The average OEF during BTO was significantly increased (21% and 43%) than that of before BTO in two cases. The two cases were considered to be non-tolerant for permanent ICA occlusion and treated without ICA sacrifice.Measurement of the CBF and OEF/CMRO2 using a rapid PET protocol before and during BTO is feasible and can be used for accurate assessment of tolerance prediction in ICA occlusion.