Dairy products, calcium intake, and risk of prostate cancer in the prostate, lung, colorectal, and ovarian cancer screening trial
Dairy products, calcium intake, and risk of prostate cancer in the prostate, lung, colorectal, and ovarian cancer screening trial
复制标题
DOI：
10.1158/1055-9965.epi-07-0601
复制
发表时间：
2007-12-01
影响因子：
3.8
通讯作者：
Hayes, Richard B.
中科院分区：
文献类型：
--
作者：
Ahn, Jiyoung;Albanes, Demetrius;Hayes, Richard B.
据报道，钙和乳制品（膳食钙的主要来源）的摄入量增加会增加患前列腺癌的风险，这可能是由于钙摄入量增加会减少循环维生素D。在前列腺癌、肺癌、结直肠癌和卵巢癌筛查试验中，我们前瞻性地研究了29509名男性乳制品和钙摄入量与前列腺癌风险的关系，其中包括1910例。在前列腺、肺、结直肠和卵巢试验亚研究（n = 275）中，我们还评估了钙摄入量与血清25-羟基维生素D [25(OH)D]和1,25-二羟基维生素D [1,25(OH)(2)D]的关系。使用食物频率问卷评估饮食摄入量。血清1,25(OH)2D基线采用RIA测定。大量摄入乳制品，尤其是低脂乳制品，与前列腺癌风险增加呈弱相关[相对危险度（RR）， 1.12；95%置信区间（CI） 0.97-1.30；P趋势= 0.06,>2.75 vs . 2000 vs .
Higher intakes of calcium and dairy products, a major source of dietary calcium, are reported to increase the risk of prostate cancer, potentially due to reductions in circulating vitamin D with increasing calcium intake. We prospectively examined the association of dairy product and calcium intake with prostate cancer risk in 29,509 men, including 1,910 cases, in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. We also evaluated the relation of calcium intake with serum 25-hydroxy-vitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)(2)D], in a Prostate, Lung, Colorectal, and Ovarian Trial substudy (n = 275). Dietary intake was assessed using a food frequency questionnaire. Baseline serum 1,25(OH)2D was determined by RIA. Greater intake of dairy products, particularly low-fat dairy products, was weakly associated with increased risk of prostate cancer [relative risk (RR), 1.12; 95% confidence intervals (CI), 0.97-1.30; P trend = 0.06 for >2.75 versus 2,000 versus