Protein C in the neonatal period.
Protein C in the neonatal period.
复制标题
新生儿期的蛋白质C。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
K. Yoshioka
中科院分区：
文献类型：
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作者：
O. Takamiya;S. Kinoshita;K. Niinomi;K. Yoshioka
对141名足月婴儿在出生后第一个月内的蛋白- c活性和抗原进行了测定。脐带血中蛋白- c活性和抗原水平约为正常成人的三分之一，在生命的第1至第2天显著低于脐带血。它们随着年龄的增长而逐渐增加，但即使在第一个月也没有达到正常成年人的最低限度。一些婴儿在出生后4天内表现出蛋白- c活性与抗原的低比例。在Ca2+存在的情况下，琼脂糖凝胶电泳显示，新生儿的沉淀弧在蛋白- c活性和抗原水平之间存在差异。新生儿期蛋白C异常可认为是维生素k缺乏或拮抗剂所致的蛋白异常。
Protein-C activity and antigen were measured in 141 full-term infants during the first month of life. The levels of both protein-C activity and antigen were about one third the level for normal adults in cord blood, and significantly lower than the cord blood during the 1st to 2nd days of life. They increased with age progressively, but did not reach the lowest limit in normal adults even in the first month. The low ratio of protein-C activity and antigen was demonstrated in some infants within the first 4 days of life. The precipitin arc of neonatal infants, which had a discrepancy between protein-C activity and antigen levels, showed an anodal shift upon agarose gel electrophoresis in the presence of Ca2+. The abnormal protein C in the neonatal period may be regarded as protein induced by vitamin-K absence or antagonist.