A brief smell identification test discriminates between deficit and non-deficit schizophrenia
A brief smell identification test discriminates between deficit and non-deficit schizophrenia
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DOI：
10.1016/s0165-1781(03)00194-x
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发表时间：
2003-09-30
影响因子：
11.3
通讯作者：
Malaspina, D
中科院分区：
文献类型：
--
作者：
Goudsmit, N;Coleman, E;Malaspina, D
越来越多的证据表明，精神分裂症的气味识别缺陷(SID)和社会功能障碍可能具有共同的病理生理机制。虽然大多数精神分裂症研究使用冗长的40个项目的宾夕法尼亚大学气味识别测试(UPSIT)来评估气味识别能力，但最近已经构建了一个简短的12个项目的气味识别测试(B-SIT)，作为UPSIT的文化中性替代品。通过选择UPSIT中最初产生B-SIT的12个条目，我们构建了B-SIT的替代物，并比较了83名精神分裂症患者和69名正常受试者的表现。我们检查了与UPSIT相关的B-SIT代理的部分特性，以确定其在精神科人群中的使用效果。我们考虑了B-SIT代用品的敏感性，并评估了识别缺陷综合征精神分裂症(DS)的截断值。患者组(n=83，r=0.85，P=0.01)和对照组(n=69，r=0.83，P=0.01)的UPSIT和B-SIT指标显著相关，这两项指标对DS患者和非DS患者的区别相似。本研究的结果支持了B-SIT在精神分裂症研究中的实用性，并突出了SID与精神分裂症的社会功能障碍之间关系的稳健性。(C)2003爱思唯尔爱尔兰有限公司。保留所有权利。
Evidence is accumulating that smell identification deficits (SID) and social dysfunction in schizophrenia may share a common pathophysiology. While most schizophrenia studies utilize the lengthy 40-item University of Pennsylvania Smell Identification Test (UPSIT) to assess smell identification ability, a brief 12-item smell identification test (B-SIT) has recently been constructed as a culturally neutral substitute for the UPSIT. By selecting the 12 items of the UPSIT from which the B-SIT was originally derived, we constructed a proxy for the B-SIT and compared the performance of 83 patients with schizophrenia to 69 normal Subjects. We examined select properties of the B-SIT proxy in relation to the UPSIT to determine its efficacy for use in psychiatric populations. We considered the sensitivity of the B-SIT proxy and evaluated a cutoff score for identifying deficit syndrome schizophrenia (DS). The UPSIT and B-SIT proxy were significantly related in the patients (n=83, r=0.85, P=0.01) and in comparison subjects (n=69, r=0.83, P=0.01), and both measures similarly distinguished DS from non-deficit syndrome (non-DS) patients. The results of this study support the utility of the B-SIT for schizophrenia research and highlight the robustness of the relationship between SID and social dysfunction in schizophrenia. (C) 2003 Elsevier Ireland Ltd. All rights reserved.