Chemical Structures of Polyphenols That Critically Influence the Toxicity of ZnO Nanoparticles
Chemical Structures of Polyphenols That Critically Influence the Toxicity of ZnO Nanoparticles
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严重影响 ZnO 纳米颗粒毒性的多酚化学结构
DOI：
10.1021/acs.jafc.8b00368
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发表时间：
2018
影响因子：
6.1
通讯作者：
Cao Yi
中科院分区：
文献类型：
--
作者：
Zhang Cao;Li Yining;Liu Liangliang;Gong Yu;Xie Yixi;Cao Yi
最近的研究表明，植物化学物质作为天然抗氧化剂在食品中可以减轻纳米颗粒（NP）的毒性。本研究调查了氧化锌纳米颗粒和一组多酚的联合毒性。令人惊讶的是，具有高的和几乎没有自由基清除活性的多酚可以引起对NP暴露在Caco-2细胞，这主要是由羟基的位置的影响的细胞保护作用。具有不同化学结构的多酚不同程度地影响ZnO纳米颗粒的流体动力学尺寸、zeta电位和溶解度，以及纳米颗粒诱导的细胞内超氧阴离子和锌离子，这些都可能有助于综合效应。人内皮细胞的反应似乎与Caco-2细胞的反应不同，这可能表明对NP和植物化学物质组合暴露的细胞类型依赖性反应。总之，本研究的数据表明，植物化学物质的化学结构在确定其影响ZnO NP毒性的能力中起着关键作用。
Recent studies suggested that phytochemicals as natural antioxidants in food could alleviate nanoparticle (NP) toxicity. This study investigated the combined toxicity of ZnO NPs and a panel of polyphenols. Surprisingly, polyphenols with both high and almost no radical scavenging activities could elicit cytoprotective effects against NP exposure in Caco-2 cells, which were primarily influenced by the positions of the hydroxyl group. Polyphenols with different chemical structures variously influenced the hydrodynamic size, zeta potential, and solubility of ZnO NPs as well as NP-induced intracellular superoxide and Zn ions, which could all contribute to the combined effects. Responses of human endothelial cells appeared to be different from the responses of Caco-2 cells, which may indicate cell-type dependent responses to combined exposure of NPs and phytochemicals. In conclusion, the data from this study suggested a pivotal role of chemical structures of phytochemicals in determining their capacity to affect ZnO NP toxicity.