ALTERED IMMUNOGLOBULIN EXPRESSION AND FUNCTIONAL SILENCING OF SELF-REACTIVE LYMPHOCYTES-B IN TRANSGENIC MICE
ALTERED IMMUNOGLOBULIN EXPRESSION AND FUNCTIONAL SILENCING OF SELF-REACTIVE LYMPHOCYTES-B IN TRANSGENIC MICE
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DOI：
10.1038/334676a0
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发表时间：
1988-08-25
期刊：
影响因子：
64.8
通讯作者：
BASTEN, A
中科院分区：
文献类型：
--
作者：
GOODNOW, CC;CROSBIE, J;BASTEN, A
在表达新自身抗原、鸡蛋溶菌酶和高亲和力抗溶菌酶抗体的基因的双转基因小鼠中已经证明了免疫耐受性。大多数抗溶菌酶B细胞没有经历克隆缺失，但不再能够分泌抗溶菌酶抗体，并显示出明显降低的表面IgM水平，同时继续表达高水平的表面IgD。这些发现表明，自身耐受性可能是由克隆缺失以外的机制引起的，并且与IgD在B细胞耐受性中可能具有独特作用的假设一致。
Immunological tolerance has been demonstrated in double-transgenic mice expressing the genes for a neo-self antigen, hen egg lysozyme, and a high affinity anti-lysozyme antibody. The majority of anti-lysozyme B-cells did not undergo clonal deletion, but were no longer able to secrete anti-lysozyme antibody and displayed markedly reduced levels of surface IgM while continuing to express high levels of surface IgD. These findings indicate that self tolerance may result from mechanisms other than clonal deletion, and are consistent with the hypothesis that IgD may have a unique role in B-cell tolerance.